Measurement of biological information with applications from genes to landscapes
Measurement of biological information with applications from genes to landscapes
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DOI：
10.1111/j.1365-294x.2006.02992.x
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发表时间：
2006-09-01
影响因子：
4.9
通讯作者：
Rossetto, Maurizio
中科院分区：
文献类型：
--
作者：
Sherwin, William B.;Jabot, Franck;Rossetto, Maurizio
生物多样性的量化有引物设计、生物勘探和群落生态学等方面的原因。我们建议Shannon’s H-S作为各个层次的共同指标，该指标已在信息论和生态群落生物多样性中得到应用。自从列万廷首次使用这一索引来描述人类遗传变异以来，它已被用于病毒变异、剪接和家谱的信息性。然而，到目前为止，还没有理论来预测在给定的遗传和人口条件下该指数的期望值。我们提出了一个新的遗传水平的H-S零理论，并表明该指标具有以下优点：(1)在组织的每个层次水平上测量的独立性；（ii）对各种条件下的遗传交换进行可靠的估计；纳入人口规模资料的能力；（四）与标准统计检验的显式关系。将该指数与其他现有指数结合使用，可以对遗传过程提供强有力的见解。我们的遗传理论也可以扩展到生态群落水平，因此可以帮助在遗传和群落水平上比较和整合多样性，包括需要包含物种之间遗传差异的群落多样性测量。
Biological diversity is quantified for reasons ranging from primer design, to bioprospecting, and community ecology. As a common index for all levels, we suggest Shannon's H-S, already used in information theory and biodiversity of ecological communities. Since Lewontin's first use of this index to describe human genetic variation, it has been used for variation of viruses, splice-junctions, and informativeness of pedigrees. However, until now there has been no theory to predict expected values of this index under given genetic and demographic conditions. We present a new null theory for H-S at the genetic level, and show that this index has advantages including (i) independence of measures at each hierarchical level of organization; (ii) robust estimation of genetic exchange over a wide range of conditions; (iii) ability to incorporate information on population size; and (iv) explicit relationship to standard statistical tests. Utilization of this index in conjunction with other existing indices offers powerful insights into genetic processes. Our genetic theory is also extendible to the ecological community level, and thus can aid the comparison and integration of diversity at the genetic and community levels, including the need for measures of community diversity that incorporate the genetic differentiation between species.