DOPAMINE SUPERSENSITIVITY AND HORMONAL STATUS IN PUERPERAL PSYCHOSIS
DOPAMINE SUPERSENSITIVITY AND HORMONAL STATUS IN PUERPERAL PSYCHOSIS
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DOI：
10.1192/bjp.166.1.73
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发表时间：
1995-01-01
影响因子：
10.5
通讯作者：
JONES, SR
中科院分区：
文献类型：
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作者：
MEAKIN, CJ;BROCKINGTON, IF;JONES, SR
背景。我们检验了产褥期精神病的多巴胺受体超敏感假说，并探讨了该受体系统功能敏感性在产褥期的变化。使用生长激素（GH）对阿波啡刺激的反应来估计多巴胺受体的敏感性，37名对照妇女分娩后，11名分娩的10名妇女有产褥期精神病的“高风险”（既往有产褥期情感性或非产褥期躁狂精神病）。在产后第4或5天，第11或12天以及第6周进行了检查结果3例产后精神病患者在第4天出现生长激素亚敏感反应。生长激素对67次刺激试验的反应（对照组和“高风险”妇女）在产后4、5天和6周之间增加(P
Background. We examine the dopamine receptor supersensitivity hypothesis of puerperal psychosis, and explore puerperal changes in the functional sensitivity of this receptor system.Method. Dopamine receptor sensitivity was estimated using growth hormone (GH) response to apomorphine challenge following delivery in 37 control women, and 11 deliveries in 10 women at 'high risk' of puerperal psychosis (previous history of puerperal affective or nonpuerperal manic psychosis). Tests were on days 4 or 5, 11 or 12 and at six weeks postpartum.Results. Three women developing puerperal psychosis had subsensitive GH responsiveness on day 4. GH response to 67 challenge tests (in control and 'high risk' women) increased between days 4 or 5 and six weeks postpartum (P