Determination of trace bisphenols in milk based on Fe3O4@NH2-MIL-88(Fe)@TpPa magnetic solid-phase extraction coupled with HPLC
Determination of trace bisphenols in milk based on Fe3O4@NH2-MIL-88(Fe)@TpPa magnetic solid-phase extraction coupled with HPLC
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Fe3O4@NH2-MIL-88(Fe)@TpPa磁力固相萃取-HPLC测定牛奶中痕量双酚
DOI：
10.1016/j.talanta.2023.124268
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发表时间：
2023
期刊：
影响因子：
6.1
通讯作者：
Xiupei Yang
中科院分区：
文献类型：
--
作者：
Qingying Wang;Lianfang Chen;Xiaoyan Cui;Jie Zhang;Yaohui Wang;Xiupei Yang
本文采用溶剂热法在磁性金属有机骨架(MOF)上生长了共价有机骨架(COF)，用于高效提取双酚类化合物(BPS)。在不调节pH和盐浓度的情况下，对双酚A、双酚B、双酚AF和双酚C四种双酚进行了磁性固相萃取。当用30 mg Fe3O4@NH2-MIL-88(Fe)@TPPA吸附25min，用6mL甲醇洗脱20min时，提取液用高效液相色谱(HPLC)检测。方法的检出限为0.011~0.036 ng/mL−1，线性范围为0.036~100 ng/mL−1，相关系数(R2)为0.9980~0.9998。日内和日间精密度分别为0.74-2.54%和1.68-3.72%。将该方法应用于实际牛奶样品中双酚A的测定。标准加入实验表明，四种双酚的相对回收率为85.70-119.7%。用准秒级、一级、Langmuir和Freundlich模型研究了Fe3O4@NH2-MIL-88(Fe)@TPPA的吸附特性。总体而言，建立的Fe3O4@NH2-MIL-88(Fe)@TPPA-MSPE-HPLC-UV方法灵敏度高、操作简便、重复性好，在复杂牛奶基质中痕量苯并苯的检测中具有良好的应用前景。
Herein, a covalent organic framework (COF) was grown on a magnetic metal-organic framework (MOF) by a solvothermal method for the efficient extraction of bisphenols (BPs). The magnetic solid-phase extraction (MSPE) of four bisphenols (bisphenol A, bisphenol B, bisphenol AF and bisphenol C) was carried out without adjusting the pH and salt concentration. When 30 mg Fe3O4@NH2-MIL-88(Fe)@TpPa was used to adsorb for 25 min, 6 mL methanol was used to elute for 20 min, and the extract was detected by high-performance liquid chromatography (HPLC). The proposed method has a low detection limit of 0.011–0.036 ng mL−1, a wide linear range of 0.05–100 ng mL−1, and a correlation coefficient (R2) of 0.9980–0.9998. The intra-day and inter-day precisions are 0.74–2.54% and 1.68–3.72%, respectively. Bisphenol A was determined by applying the proposed method to the determination of actual milk samples. The standard addition experiment showed that the relative recovery of the four bisphenols was 85.70–119.7%. Pseudosecond-order, first-order, Langmuir and Freundlich models were applied to explore the adsorption characteristics of Fe3O4@NH2-MIL-88(Fe)@TpPa. In general, the established Fe3O4@NH2-MIL-88(Fe)@TpPa-MSPE-HPLC-UV method exhibits attractive sensitivity, simple manipulation, and excellent reusability, and it has excellent prospects for the detection of trace BPs in complex milk matrices.