A randomized trial on effects of hormone therapy on ambulatory blood pressure and lipoprotein levels in women with coronary artery disease
A randomized trial on effects of hormone therapy on ambulatory blood pressure and lipoprotein levels in women with coronary artery disease
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DOI：
10.1097/00004872-199917100-00004
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发表时间：
1999-10-01
影响因子：
4.9
通讯作者：
Schenck-Gustafsson, K
中科院分区：
文献类型：
--
作者：
Pripp, U;Hall, G;Schenck-Gustafsson, K
目的探讨激素替代疗法（HRT）对绝经后冠心病（CAD）妇女1年动态血压（ABP）和脂蛋白水平的影响。方法60例平均年龄（+/- SD）为59 +/- 7岁的患者随机分为3组：偶联马雌激素（CEE） 0.625 ma / d (n = 20)， 17 β -雌二醇（TTSE） 50 μ g / 24 h （n = 20）或安慰剂（n = 20）组，连续18 d，然后联合醋酸甲孕酮5 mg，连续10 d。每28天为一个周期，重复1年。结果1年后，CEE组18名妇女中有15名夜间收缩期ABP下降9.6% (P = 0.0075)，安慰剂组13名妇女中有12名下降22% （P = 0.0034）。在CEE组，从基线到6个月，18名妇女中有13名白天收缩期ABP上升4.6% (P < 0.05)，夜间收缩期ABP上升4.2% （P < 0.05）。在CEE组（分析了14名妇女）中，1年后，13名妇女的高密度脂蛋白水平上升了15.8% (P = 0.0018)， 12名妇女的低密度脂蛋白水平下降了15.2% (P = 0.0129)， 11名妇女的总胆固醇水平下降了7.5% （P = 0.057）。甘油三酯水平没有变化。在TTSE组和安慰剂组中，分别分析了12名和13名妇女，没有出现明显的变化。结论CAD患者1年HRT治疗对ABP无影响，口服HRT对脂蛋白水平有有益影响。[J]中国医学工程学报，1997,17(5):579 - 586。
Objective To investigate 1-year effects of hormone replacement therapy (HRT) on ambulatory blood pressure (ABP) and lipoprotein levels in postmenopausal women with coronary artery disease (CAD).Methods Sixty patients at a mean age (+/- SD) of 59 +/- 7 years were randomized into three groups: conjugated equine oestrogens (CEE) 0.625 ma daily (n = 20), 50 mu g 17 beta-oestradiol transdermally (TTSE) per 24 h (n = 20) or placebo (n = 20) for 18 days, then combined with medroxyprogesterone acetate 5 mg for 10 days. Each cycle of 28 days was repeated for one year.Results Night-time systolic ABP had decreased by 9.6% (P = 0.0075) in 15 of 18 women in the CEE group and by 22% in 12 of 13 women (P = 0.0034) in the placebo group after 1 year. In the CEE group, a 4.6% rise in daytime systolic ABP (P < 0.05) and a 4.2% rise in night-time systolic ABP (P < 0.05) appeared from baseline to 6 months in 13 of 18 women. In the CEE group (14 women analysed), high-density lipoprotein levels showed a 15.8% increase (P = 0.0018) in 13 women, low-density lipoprotein levels a 15.2% decrease (P = 0.0129) in 12 women and total cholesterol levels a 7.5% decrease (P = 0.057) in 11 women after 1 year. Triglyceride levels showed no changes. In the TTSE group and in the placebo group, with 12 and 13 women analysed respectively, no significant changes appeared.Conclusions One year of HRT in patients with CAD does not influence ABP, Oral HRT induces beneficial effects on lipoprotein levels. J Hypertens 1999, 17:1379-1386 (C) Lippincott Williams & Wilkins.