Properties of developmental gene regulatory networks
Properties of developmental gene regulatory networks
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DOI：
10.1073/pnas.0806007105
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发表时间：
2008-12-23
影响因子：
11.1
通讯作者：
Levine, Michael S.
中科院分区：
文献类型：
--
作者：
Davidson, Eric H.;Levine, Michael S.
发育基因调控网络（GRN）的模块化组件或子电路执行特定的发育功能，例如细胞身份的规范。我们调查了此类子电路的例子，并将它们的结构与相应的发育功能联系起来。这些关系超越了生物体和基因，正如控制果蝇胚胎中外胚层和海胆内中胚层规格的子电路的相似结构所说明的那样，尽管各自的子电路是由非直系同源的调节基因组成的。
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.