Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus
Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus
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吗替麦考酚酯在治疗副肿瘤性天疱疮中的用途
DOI：
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发表时间：
2000
影响因子：
10.3
通讯作者：
E. M. Billingsley
中科院分区：
文献类型：
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作者：
J. V. Williams;J. V. Williams;James G. Marks;E. M. Billingsley
副肿瘤性天疱疮是一种罕见的自身免疫性水疱性疾病，其循环抗体结合在表皮和其他非复层上皮细胞表面，免疫沉淀由4或5个蛋白质组成的复合体(250 kDa，230 kDa，210 kDa，190 kDa，偶尔170 kDa)。通常需要1、2种免疫抑制剂的组合才能部分控制皮损。3粘膜病变难治。我们描述了一例PNP患者，在口服霉酚酸酯治疗后，其皮肤和口腔皮损静止。
Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non‐stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). 1, 2 Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions. 3 Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.