Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics
Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics
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DOI：
10.1016/s0006-3223(03)00005-2
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发表时间：
2003-12-15
影响因子：
10.6
通讯作者：
Irwin, MR
中科院分区：
文献类型：
--
作者：
Kühlwein, E;Hauger, RL;Irwin, MR
背景资料：酒精中毒患者的脑电图显示出明显的睡眠障碍，睡眠的开始和维持都有困难。鉴于褪黑激素在睡眠-觉醒周期调节中的作用，本研究检测了与对照组相比，酒精中毒患者（n = 11）和对照组（n = 10）夜间褪黑激素表达与睡眠之间的关系。30 AM测量褪黑激素和皮质醇的循环水平。再加上睡眠潜伏期延长，酗酒者在夜间早期表现出较低的褪黑激素水平，与对照组相比，控制对象。褪黑素的夜间延迟与睡眠潜伏期延长相关。皮质醇的循环水平较低，在夜间的早期部分和更高，在深夜的酗酒者相比，控制subjects.Conclusions：延迟在夜间上升的褪黑激素可能会导致睡眠障碍的慢性酗酒者，使用褪黑激素在治疗失眠的恢复酗酒者的影响。
Background: Alcoholic patients show prominent disturbance of sleep as measured by electroencephalogram, with difficulties in the onset and maintenance of sleep. Given the role of melatonin in the regulation of the sleep-wake cycle, this study examined the relationship between nocturnal expression of melatonin and sleep in alcoholics as compared with control subjects.Methods: Alcoholic patients (n = 11) and comparison control subjects (n = 10) underwent all-night polysomnography and serial blood sampling every 30 min from 10:00 PM to 6:30 AM for measurement of circulating levels of melatonin and cortisol.Results: Coupled with prolonged sleep latency, alcoholics showed lower levels of melatonin during the early part of the night and a delay in the onset of the nocturnal plateau or peak value of melatonin as compared with control subjects. The nocturnal delay of melatonin correlated with prolonged sleep latency. Circulating levels of cortisol were lower during the early part of the night and higher in the late part of night in the alcoholics as compared with the control subjects.Conclusions: A delay in the nocturnal rise of melatonin may contribute to disordered sleep in chronic alcoholics, with implications for the use of melatonin in the treatment of insomnia in recovering alcoholics.