Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling
Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling
复制标题
环状RNA泛素相关蛋白2通过miR-582-5p/FOXO1信号通路增强自噬，促进结直肠癌的进展和转移
DOI：
10.1016/j.jgg.2021.07.017
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发表时间：
2021-12-01
影响因子：
5.9
通讯作者：
Pei, Dongsheng
中科院分区：
文献类型：
--
作者：
Chen, Feifei;Guo, Lei;Pei, Dongsheng
许多环状RNA（circRNA）已被鉴定为各种癌症中的重要调节因子。新报道的环状RNA泛素相关蛋白2（circUBAP 2）是各种类型癌症中细胞生长和转移的关键参与者，尽管其在结直肠癌（CRC）中的作用尚未完全阐明。我们发现circUBAP 2在CRC组织和细胞系中上调以诱导体外和体内的自噬。circUBAP 2对迁移、侵袭和增殖的影响可能部分与自噬有关。从机制上讲，我们发现circUBAP 2可以直接与miR-582- 5 p相互作用，随后作为microRNA海绵调节miR-582- 5 p靶基因叉头盒蛋白O 1（FOXO 1）和下游信号分子的表达，共同促进CRC的进展和转移。这些结果表明，circUBAP 2通过新的circUBAP 2/miR-582- 5 p/FOXO 1轴作为癌基因发挥作用，为CRC管理提供了潜在的生物标志物和治疗靶点。中国科学院遗传与发育生物学研究所版权所有（C）2021由爱思唯尔有限公司和科学出版社出版。All rights reserved.
Numerous circular RNAs (circRNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2 (circUBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer (CRC) has yet to be fully elucidated. We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circUBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circUBAP2 can directly interact with miR-582-5p and subsequently act as a microRNA sponge to regulate the expression of the miR-582-5p target gene forkhead box protein O1 (FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circUBAP2 acts as an oncogene via a novel circUBAP2/miR-582-5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.