Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors
Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors
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DOI：
10.1590/s0004-27302011000300007
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发表时间：
2011-04-01
期刊：
影响因子：
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通讯作者：
Niepomniszcze, Hugo
中科院分区：
文献类型：
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作者：
Pitoia, Fabián;Cross, Graciela;Niepomniszcze, Hugo
目的：本研究的目的是确定家族性非髓样甲状腺癌（FNMTC）是否比散发性甲状腺癌更具侵袭性。研究对象和方法：我们比较了来自7个无亲缘关系亲属的16例FNMTC患者的临床行为和预后，与我们数据库中160例散发性PTC （SPTC）患者的临床行为和预后。结果：两组患者唯一的基线差异为：双侧恶性肿瘤，分别为38%和24% (p = 0.03)，淋巴结转移，分别为56.2%和39% （p = 0.01）。考虑到结果，在FNMTC中，9例（56.2%）患者无疾病，1例（6%）患者死于甲状腺癌，6/16（37.5%）患者有持续性疾病。在SPTC组中，87例（54%）患者被认为无疾病，11例（7%）患者死于PTC， 62例（38%）患者有持续性疾病（p = ns）。结论：尽管FNMTC患者的淋巴结转移发生率较高，但这种情况似乎并未改变比较结果。中华医学杂志；2011；55(3): 219 - 23所示
Objective: The purpose of this study was to determine whether familial non-medullary thyroid cancer (FNMTC) is more aggressive than sporadic thyroid cancer. Subjects and methods: We compared the clinical behavior and outcome of 16 subjects with FNMTC from 7 unrelated kindred with those observed in 160 subjects with sporadic PTC (SPTC) from our database. Results: The only different baseline characteristics observed between both groups were: bilateral malignancy, 38% vs. 24%, respectively (p = 0.03), and lymph node metastasis, 56.2% vs. 39%, respectively (p = 0.01). Considering the outcome, in the FNMTC, 9 (56.2%) patients were rendered free of disease, one patient died from thyroid cancer (6%), and 6/16 (37.5%) had persistent disease. In the SPTC Group, 87 (54%) patients were considered free of disease, 11 (7%) died due to PTC, and 62 (38%) had persistent disease (p = ns). Conclusions: Despite the higher incidence of lymph node metastasis in FNMTC patients this situation seemed not to alter the compared outcome. Arq Bras Endocrinol Metab. 2011;55(3):219-23