Islet architecture: A comparative study.
Islet architecture: A comparative study.
复制标题
作者：
Kim A;Miller K;Jo J;Kilimnik G;Wojcik P;Hara M
关于人类胰岛中不同激素分泌细胞类型（α，胰高血糖素，β，胰岛素和δ，生长抑素）组织的新报告强调了人类和小鼠胰岛之间的明显差异，提出了关于小鼠胰岛研究与人类胰岛生理学相关性的问题。在这里，我们研究了人类和小鼠胰岛结构的异同。我们研究了各种小鼠模型的胰岛，包括ob/ob和db/db以及怀孕小鼠。为了进一步比较，我们还研究了猴子、猪、兔子和鸟类的胰岛。尽管这些物种的全身和胰腺大小以及总β细胞质量存在差异，但它们的胰岛大小分布密切重叠，除了鸟类的胰腺中δ细胞群体占主导地位（无论是单细胞还是集群）以及少量的胰岛。人类和猴子的胰岛以及ob/ob和妊娠小鼠的胰岛均观察到明显的大胰岛（bbb10 000 μm2）。胰岛内α-、β-和δ-细胞的比例在所有物种的胰岛之间有所不同。α-细胞和δ-细胞在同一种内的分布也存在差异。总之，人类和小鼠胰岛具有共同的结构特征，可能反映了对胰岛素的需求。对岛屿建筑的比较研究可以更好地理解岛屿的发展和功能。
Emerging reports on the organization of the different hormone-secreting cell types (α, glucagon; β, insulin; and δ, somatostatin) in human islets have emphasized the distinct differences between human and mouse islets, raising questions about the relevance of studies of mouse islets to human islet physiology. Here, we examine the differences and similarities between the architecture of human and mouse islets. We studied islets from various mouse models including ob/ob and db/db and pregnant mice. We also examined the islets of monkeys, pigs, rabbits and birds for further comparisons. Despite differences in overall body and pancreas size as well as total β-cell mass among these species, the distribution of their islet sizes closely overlaps, except in the bird pancreas in which the δ-cell population predominates (both in singlets and clusters) along with a small number of islets. Markedly large islets (>10,000 μm2) were observed in human and monkey islets as well as in islets from ob/ob and pregnant mice. The fraction of α-, β- and δ-cells within an islet varied between islets in all the species examined. Furthermore, there was variability in the distribution of α- and δ-cells within the same species. In summary, human and mouse islets share common architectural features that may reflect demand for insulin. Comparative studies of islet architecture may lead to a better understanding of islet development and function.