Multiple genotypes of influenza B virus circulated between 1979 and 2003
Multiple genotypes of influenza B virus circulated between 1979 and 2003
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DOI：
10.1128/jvi.78.23.12817-12828.2004
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Iverson, AR
中科院分区：
文献类型：
--
作者：
McCullers, JA;Saito, T;Iverson, AR
B型流感病毒的基因组分段使得共循环毒株之间的基因片段可以交换。通过这种重组过程，在一个或多个基因片段不同的病毒之间混合基因产生多样性。对1979年至2003年分离的31种乙型流感B病毒的所有11个基因进行系统发育和进化分析，以研究整个基因组的进化。所有11个基因在1987年之前分化成两个新的谱系。除了NS1基因外，所有基因都经历了线性进化，尽管进化的速率和核苷酸变化转化为氨基酸变化的程度在谱系之间和基因之间存在差异。频繁的重配产生了14种不同的基因型，与1979年之前流行的病毒基因群不同。多个基因型共循环在一些地方，随着时间的推移，一系列的重配事件无法建立。令人惊讶的多样性的病毒，不受限制的混合谱系，并缺乏证据的基因片段的共同进化不支持的假设，即重配过程是由选择驱动的功能差异。
The segmented genome of influenza B virus allows exchange of gene segments between cocirculating strains. Through this process of reassortment, diversity is generated by the mixing of genes between viruses that differ in one or more gene segments. Phylogenetic and evolutionary analyses of all 11 genes of 31 influenza B viruses isolated from 1979 to 2003 were used to study the evolution of whole genomes. All 11 genes diverged into two new lineages prior to 1987. All genes except the NS1 gene were undergoing linear evolution, although the rate of evolution and the degree to which nucleotide changes translated into amino acid changes varied between lineages and by gene. Frequent reassortment generated 14 different genotypes distinct from the gene constellation of viruses circulating prior to 1979. Multiple genotypes cocirculated in some locations, and a sequence of reassortment events over time could not be established. The surprising diversity of the viruses, unrestricted mixing of lineages, and lack of evidence for coevolution of gene segments do not support the hypothesis that the reassortment process is driven by selection for functional differences.