Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness
Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness
复制标题
DOI：
10.1016/j.jpeds.2005.06.008
复制
发表时间：
2005-11-01
影响因子：
5.1
通讯作者：
Zakopoulos, N
中科院分区：
文献类型：
--
作者：
Stabouli, S;Kotsis, V;Zakopoulos, N
目的探讨24小时动态血压，血脂谱，颈动脉，内膜中层厚度（IMT）在青少年与nonobesity.Study设计的动态血压数据从93个连续的青少年提到我们的高血压中心可能的高血压进行了分析。测量所有受试者的空腹血糖和血脂浓度。所有患者均行颈动脉B型超声检查，测量颈动脉IMT。肥胖定义为体重指数>=年龄和性别的第95百分位数。22例肥胖者和71例非肥胖者。结果肥胖者的平均24小时、白天和夜间收缩压显著高于非肥胖者（P <0.002）。肥胖者的24小时、白天和夜间脉压也明显较高（P <0.001）。收缩期白色被毛效应的幅度在肥胖受试者中显著更高（P < .006），白色被毛高血压在肥胖受试者中显著更常见（P < .0001）。与非肥胖受试者相比，肥胖受试者的甘油三酯较高（P <0.001），HDL胆固醇较低（P <0.01）。结论肥胖青少年的动态血压和颈动脉UNIT均高于非肥胖青少年（P <0.005），提示肥胖相关性高血压和颈动脉结构改变的早期病程。
Objectives To investigate 24-hour ambulatory blood pressure, lipid profiles, and carotid artery, intimal-medial thickness (IMT) in adolescents with and without obesity.Study design Ambulatory blood pressure data from 93 consecutive adolescents referred to our hypertension center for possible hypertension were analyzed. Fasting serum glucose and lipid concentrations were measured in all subjects. Carotid artery IMT was also measured by B-mode ultrasound imaging in all patients. Obesity was defined as body mass index >= 95(th) percentile for age and sex. Twenty-two of the subjects were obese and 71 nonobese.Results Mean 24-hour, daytime, and nighttime systolic blood pressures were significantly higher in obese subjects compared with nonobese subjects (P < .002). Twenty-four-hour, daytime, and nighttime pulse pressures were also significantly higher in obese subjects (P < .001). The magnitude of systolic white coat effect was significantly higher in obese subjects (P < .006) and white coat hypertension was significantly more frequent in obese subjects (P < .0001). Obese subjects had higher triglycerides (P < .001) and lower HDL cholesterol (P < .01) than nonobese subjects. Finally, obese adolescents had thicker mean UNIT of internal carotid arteries than nonobese adolescents (P < .005).Conclusions Obese adolescents have higher ambulatory blood pressure kind higher carotid artery UNIT, possibly indicating an early course of obesity-related hypertension and carotid artery structural alterations.