The Correlation between Levels of Transforming Growth Factor-beta with Pulmonary Fibrosis in Post Pulmonary Tuberculosis in Medan, North Sumatera - Indonesia.
The Correlation between Levels of Transforming Growth Factor-beta with Pulmonary Fibrosis in Post Pulmonary Tuberculosis in Medan, North Sumatera - Indonesia.
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DOI：
10.3889/oamjms.2019.544
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发表时间：
2019-07-15
影响因子：
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通讯作者：
Ananda, Fannie Rizki
中科院分区：
文献类型：
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作者：
Christine, Tamara;Tarigan, Amira Permatasari;Ananda, Fannie Rizki
背景：未经治疗或治疗不足的肺结核可导致严重并发症直至死亡。治疗后，可能会出现残留病变。残余病变的存在是多种多样的，包括纤维化、空洞、支气管扩张和钙化。转化生长因子- β (tgf - β)是一种与肺部炎症相关的细胞因子，在肺纤维化中起作用。然而，只有少数研究评估了治疗后结核病患者的血清tgf - β水平。目的：本研究的主要目的是确定肺结核患者tgf - β水平与肺纤维化之间的相关性。设计：观察了51例接受抗结核治疗的患者，其中男性31例，女性20例。所有患者中有26人有吸烟史，其中男性25人，女性1人。经临床、实验室及影像学检查证实，所有患者均已康复。采用ELISA检测tgf - β水平，胸部x线检查肺纤维化的发生。结果：病变组（+）的tgf - β平均水平为7628.02 (SD：±4928.38)，病变组（-）的tgf - β平均水平为2315.11 （SD：±505.83）。经统计学检验，tgf - β水平与纤维化病变有显著相关性（p < 0.001）。结论：结核后合并肺纤维化患者tgf - β水平明显升高。
BACKGROUND: Untreated or undertreated, pulmonary tuberculosis could cause severe complications until death. After treatment, residual lesions might occur. The presence of residual lesions is varied, including fibrosis, cavity, bronchiectasis and calcification. Transforming growth factor-beta (TGF-beta) is a cytokine associated with lung inflammation, which plays a role in lung fibrosis. However, only a few studies have assessed the serum level of TGF-beta in post-treatment tuberculosis patients.AIM: The main objective of this study was to determine the correlation between TGF-beta levels and pulmonary fibrosis in patients with pulmonary tuberculosis.DESIGN: A group of 51 patients that had undergone anti-tuberculosis treatment were observed, consisting of 31 men, 20 women. Of all patients, there were 26 people with a smoking history, including 25 men and 1 woman. All patients had been recovered, confirmed by the clinical state, laboratory and radiology examination. The ELISA test was performed to measure TGF-beta level, while the chest X-ray was used to look for the occurrence of pulmonary fibrosis.RESULTS: The mean level of TGF-beta in patients with a lesion (+) was 7628.02 (SD: ± 4928.38) while the mean level of TGF-beta in patients with a lesion (-) was 2315.11 (SD: ± 505.83). The statistical test showed a significant relationship between TGF-beta level and fibrosis lesion (p < 0.001).CONCLUSION: TGF-beta level was significantly higher in post-tuberculosis patients with pulmonary fibrosis.