Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 μg per day: results from TMM BirThree Cohort Study
Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 μg per day: results from TMM BirThree Cohort Study
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DOI：
10.1080/14767058.2020.1739020
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发表时间：
2020-03-13
影响因子：
1.8
通讯作者：
Kuriyama, Shinichi
中科院分区：
文献类型：
--
作者：
Kikuchi, Daisuke;Obara, Taku;Kuriyama, Shinichi
目的：在日本，建议计划怀孕的妇女每天补充400微克叶酸，以降低婴儿患神经管缺陷（NTD）的风险。然而，在日本孕妇中，在怀孕前服用叶酸补充剂的女性比例很低。此外，叶酸的膳食摄入量尚未达到政府推荐的膳食摄入量水平（每天480微克）。本研究旨在阐明日本孕妇膳食叶酸摄入量低于480 μ g/天的叶酸补充剂的流行率和决定因素。方法：这项横断面研究是东北医疗Megabank项目出生和三代队列研究的一部分。我们收集了有关怀孕前叶酸补充剂、社会学/生活方式特征和食物消费的信息。主要结局是叶酸补充剂的使用（充足或不足，基于开始服用叶酸补充剂的时间）。多元逻辑回归分析被用来检查社会学/生活方式特征和叶酸补充剂的摄入量之间的关联。结果：在11,562名每日从食物中摄取叶酸低于480 μ g的孕妇中，足够使用者的比例为18.0%。报告充分使用叶酸补充剂的孕妇更有可能年龄较大，受过教育;并报告较高的家庭收入和生育治疗史。相反，她们不太可能是曾经或现在的吸烟者和经产妇。结论：这项研究发现，日本孕妇使用叶酸补充剂预防NTD的流行率仍然很低。
Objective: In Japan, supplementation with 400 mu g of folic acid per day is recommended for women who are planning to get pregnant to decrease the risk of their babies getting neural tube defects (NTD). However, the proportion of women who have taken folic acid supplements before conception is low among Japanese pregnant women. In addition, the dietary intake of folic acid has not yet reached the government recommended dietary intake levels (480 mu g per day). This study aimed to clarify the prevalence and determinants of adequate folic acid supplements among Japanese pregnant women with dietary folic acid intake lower than 480 mu g per day. Methods: This cross-sectional study was a part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We collected information on folic acid supplements before conception, sociological/lifestyle characteristics, and food consumption. The primary outcome was the use of folic acid supplements (adequate or inadequate, based on the timing of initiation of folic acid supplements). Multiple logistic regression analysis was used to examine the association between sociological/lifestyle characteristics and the adequate intake of folic acid supplements. Results: Among the 11,562 pregnant women who took lower than 480 mu g per day of folic acid from food, the prevalence of adequate users was 18.0%. Pregnant women who reported adequate use of folic acid supplements were more likely to be older and educated; and reported higher household income, and history of fertility treatment. Conversely, they were less likely to be ever or current smokers and multipara. Conclusion: This study found that the prevalence of folic acid supplements use for the prevention of NTD among Japanese pregnant women was still low.