Assessing familial aggregation of congenital cardiovascular malformations in case-control studies.
Assessing familial aggregation of congenital cardiovascular malformations in case-control studies.
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在病例对照研究中评估先天性心血管畸形的家族聚集性。
DOI：
10.1002/gepi.1370050505
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发表时间：
1988
影响因子：
2.1
通讯作者：
Ferencz,C
中科院分区：
文献类型：
--
作者：
Maestri,NE;Beaty,TH;Liang,KY;Boughman,JA;Ferencz,C
最近的数据表明，先天性心血管畸形（CCVM）的家族聚集性随索引病例中缺陷的类型而变化。使用逻辑回归模型，允许家庭成员之间的依赖性，我们计算的风险，任何CCVM的情况下，与对照组的亲属相比。在分析中使用了巴尔的摩-华盛顿婴儿研究从1981年到1985年确定的570例匹配病例和对照的3,908名一级亲属的数据。病例亲属中任何CCVM的总体风险比对照亲属增加4倍。虽然有血流病变（包括右心和左心缺损以及膜周室间隔缺损[VSD]）病例的亲属的风险增加了5倍，但无血流病变病例的亲属的风险与对照组亲属的风险无显著差异。性别、母亲年龄、母亲流产史和出生顺序对兄弟姐妹的风险没有明显影响。然而，有迹象表明，与匹配对照组的亲属相比，非白人VSD患者的亲属风险增加。然而，这些数据是不可能区分这种家庭聚集的环境和遗传来源。
Recent data indicate that the familial aggregation of congenital cardiovascular malformations (CCVM) varies with the type of defect in the index case. Using a logistic regression model that allows for dependence among family members, we calculated the risk of any CCVM to case relatives compared with relatives of controls. Data from 3,908 first‐degree relatives of 570 matched cases and controls identified from 1981 through 1985 by the Baltimore‐Washington Infant Study were used in the analyses. Overall risk for any CCVM in case relatives was increased four‐fold over that of control relatives. While relatives of cases with flow lesions (including right and left heart defects, as well as perimembranous ventricular septal defect [VSD]) had a five‐fold increase in risk, the risk to relatives of nonflow lesion cases did not differ significantly from the risk to relatives of controls. Sex, maternal age, miscarriage history in the mother, and birth order had no apparent effect on risk among siblings. However, there was an indication of increased risk in relatives of nonwhite cases with VSD compared to relatives of matched controls. However, with these data it was not possible to distinguish between environmental and genetic sources of this familial aggregation.