CELLS IN THE PRETECTAL OLIVARY NUCLEUS ARE IN THE PATHWAY FOR THE DIRECT LIGHT REFLEX OF THE PUPIL IN THE RAT
CELLS IN THE PRETECTAL OLIVARY NUCLEUS ARE IN THE PATHWAY FOR THE DIRECT LIGHT REFLEX OF THE PUPIL IN THE RAT
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DOI：
10.1016/0006-8993(84)91340-4
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
CICERONE, CM
中科院分区：
文献类型：
--
作者：
TREJO, LJ;CICERONE, CM
戴帽大鼠前顶盖中 148 个单细胞的细胞外微电极记录根据其视网膜感受野光刺激的时间响应特性进行分类。细胞(56)被分类为强直细胞，22个被分类为强直关闭细胞，53个被分类为阶段性细胞。无法将 17 个单元分配到这 3 组中的一组。强直的顶盖前细胞的感受野中心的直径聚集在平均 31° 左右。这些细胞的时间反应是持续的。对侧瞳孔的收缩是通过记录电极在含有强直性顶盖前细胞的部位进行电刺激产生的，但在含有强直性关闭前顶盖细胞或阶段性顶盖前细胞的部位不产生。显然，强直细胞可能介导大鼠瞳孔对光反射的收缩。感受野图以及记录和刺激部位的电解标记病变显示，强直的顶盖前细胞是视网膜组织的，并且聚集在从顶盖的背内侧尖端到腹外侧边界的条带中。这些细胞的解剖分布与大鼠顶盖前橄榄核（PO）区域共同延伸。使用精细微电极，从 27 个被认为是光学起源（纤维）的轴突获得记录。其中，14 个为强音开启，10 个为阶段性，2 个为强音关闭，2 个未分类。来自强直纤维的记录是在强直前顶盖细胞附近获得的，通常在前顶盖最背侧的光反应区域。这些纤维通过视交叉的单脉冲电刺激被激活。 6个tonic-on纤维的平均感受野中心直径为10.1°，或者比顶盖前tonic-on细胞的平均感受野中心直径小约3倍。 14根强直纤维的平均传导速度为3.1 m/s。显然，PO 的强直细胞用于将来自强直中央视网膜神经节细胞的信号与相邻感受野整合起来，为动眼神经核中的神经元提供瞳孔收缩的信号。
Extracellular microelectrode recordings from 148 single cells in the pretectum of the hooded rat were classified according to their temporal response properties to light stimulation of their retinal receptive fields. Cells (56) were classified as tonic-on cells, 22 were classified as tonic-off cells, and 53 were classified as phasic cells. Seventeen cells could not be assigned to one of these 3 groups. The diameters of the receptive field centers of the tonic-on pretectal cell were clustered about a mean of 31.degree. and the temporal response of these cells was sustained. Constriction of the contralateral pupil was produced by electrical stimulation through the recording electrode at sites containing tonic-on pretectal cells, but not at sites containing tonic-off pretectal cells or phasic pretectal cells. Apparently, tonic-on cells are likely to mediate constriction in the light reflex of the rat''s pupil. Receptive field maps together with electrolytic marking lesions at recording and stimulation sites showed tonic-on pretectal cells are retinotopically organized and are aggregated in a strip running from the dorso-medial tip of the pretectum to the ventro-lateral boundary. The anatomical distribution of these cells is coextensive with the region known as the pretectal olivary nucleus (PO) in the rat. Using fine microelectrodes, recordings were obtained from 27 axons presumed to be of optic origin (fibers). Of these, 14 were tonic-on, 10 were phasic, 2 were tonic-off, and 2 were unclassified. Recordings from tonic-on fibers were obtained near tonic-on pretectal cells, typically in the most dorsal light-responsive region of the pretectum. These fibers were activated by single pulse electrical stimulation of the optic chiasm. The mean receptive field center diameter of 6 tonic-on fibers was 10.1.degree., or about a factor of 3 less than that of pretectal tonic-on cells. The mean conduction velocity of 14 tonic-on fibers was 3.1 m/s. Evidently, the tonic-on cells of the PO serve to integrate signals from tonic-on center retinal ganglion cells with adjacent receptive fields to provide signals for constriction of the pupil to neurons in the oculomotor nucleus.