Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.
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DOI：
10.1038/bjc.1957.43
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发表时间：
1957-09
影响因子：
8.8
通讯作者：
RICHARDSON, W W
中科院分区：
文献类型：
--
作者：
BLOOM, H J;RICHARDSON, W W
对于可手术的乳腺癌的最佳治疗方法，目前仍没有普遍的共识。我们认为，在评估较大和较小手术方式的相对优点以及放射治疗在这些病例中的价值方面的困难，主要是由于对结果组的比较，而这些结果组并不具有严格的可比性。即使在年龄相同、症状持续时间相同、肿瘤临床范围可比的患者中，乳腺癌病例的进展也有很大的差异。晚期疾病和长期病史的妇女可能在有限的治疗后存活多年，而一些早期住院的患者似乎是局部生长，可能在根治性手术后12个月内死于转移，
THERE is still no general agreement as to the most suitable method of treating operable carcinoma of the breast. We believe that the difficultes in assessing the relative merits of greater and lesser surgical procedures, and the value of radiotherapy in these cases is largely dueto the comparison of resultsin groups ofpatients which are not strictly comparable.There is great variation in the progress of cases of breast cancer even in patients of the same age, with the same duration of symptoms, and with tumnours of com-parable clinical extent. Women with advanced disease and a long history may survive for many years followingonly limited treatment, whilst some patients who attend hospital early with what appears to be a localised growth, may die of metastases within twelve months of radical surgery and a full course of post-