The 5-HTTLPR Polymorphism in the Serotonin Transporter Gene Moderates the Association Between Emotional Behavior and Changes in Marital Satisfaction Over Time
The 5-HTTLPR Polymorphism in the Serotonin Transporter Gene Moderates the Association Between Emotional Behavior and Changes in Marital Satisfaction Over Time
复制标题
DOI：
10.1037/a0033761
复制
发表时间：
2013-12-01
期刊：
影响因子：
4.2
通讯作者：
Levenson, Robert W.
中科院分区：
文献类型：
--
作者：
Haase, Claudia M.;Saslow, Laura R.;Levenson, Robert W.
为什么有些人在消极情绪水平高而积极情绪水平低的情况下对婚姻不满意，而另一些人则不受影响？利用一项对长期婚姻中的中年和老年人进行的13年纵向研究的数据，我们研究了5-羟色胺转运体基因中的5-HTTLPR多态性是否会调节消极和积极情绪行为（在婚姻冲突中客观测量）之间的关联以及婚姻满意度随时间的变化。对于具有5-HTTLPR两个短等位基因的个体来说，时间1时较高的消极情绪行为和较低的积极情绪行为预测婚姻满意度会随着时间的推移而下降（即使在控制了抑郁症和其他协变量之后）。对于具有一个或两个长等位基因的个体，情感行为并不能预测婚姻满意度的变化。我们还发现了交叉互动的证据（具有两个短等位基因的5-HTTLPR和低水平的消极或高水平的积极情绪的个体具有最高水平的婚姻满意度）。这些发现提供了第一个证据，证明一种特定的遗传多态性可以调节情绪行为与婚姻满意度随时间变化之间的关联，并且与越来越多的证据相一致，即这种多态性的短等位基因作为一种易感因素，可以放大对消极和积极情绪影响的敏感性。
Why do some individuals become dissatisfied with their marriages when levels of negative emotion are high and levels of positive emotions are low, whereas others remain unaffected? Using data from a 13-year longitudinal study of middle-aged and older adults in long-term marriages, we examined whether the 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between negative and positive emotional behavior (objectively measured during marital conflict) and changes in marital satisfaction over time. For individuals with two short alleles of 5-HTTLPR, higher negative and lower positive emotional behavior at Time 1 predicted declines in marital satisfaction over time (even after controlling for depression and other covariates). For individuals with one or two long alleles, emotional behavior did not predict changes in marital satisfaction. We also found evidence for a crossover interaction (individuals with two short alleles of 5-HTTLPR and low levels of negative or high levels of positive emotion had the highest levels of marital satisfaction). These findings provide the first evidence of a specific genetic polymorphism that moderates the association between emotional behavior and changes in marital satisfaction over time and are consistent with increasing evidence that the short allele of this polymorphism serves as a susceptibility factor that amplifies sensitivity to both negative and positive emotional influences.