Vascular endothelial growth factor (VEGF) in astrocytic gliomas - a prognostic factor?
Vascular endothelial growth factor (VEGF) in astrocytic gliomas - a prognostic factor?
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DOI：
10.1023/a:1006333005563
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发表时间：
1999-01-01
影响因子：
3.9
通讯作者：
Schlegel, U
中科院分区：
文献类型：
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作者：
Oehring, RD;Miletic, M;Schlegel, U
星形细胞胶质瘤的生存率与WHO肿瘤分级密切相关。在一个肿瘤等级内，特别是在II级和III级肿瘤中，临床过程是可变的，并且很难通过组织学标准预测。新生血管是高级别胶质瘤的一个神经病理学标志，血管生成因子可能在恶性肿瘤的进展中起重要作用。因此，162个原发性星形细胞胶质瘤（57个星形细胞瘤WHO II级，27个星形细胞瘤WHO III级和78个胶质母细胞瘤WHO IV级）的表达血管内皮生长因子（VEGF），这被认为是代表星形细胞胶质瘤的主要血管生成因子进行了化学研究。记录已知影响预后的临床数据。VEGF在57例星形细胞瘤中的表达率分别为36.8%（21/57）、66.7%（18/27）和64.1%（50/78）。在整个研究组中发现VEGF表达与生存率之间存在很强的相关性，然而，在一个肿瘤级别内，这种相关性并不明显。在多因素分析中，没有发现VEGF表达是星形细胞胶质瘤的独立预后因素。
Survival in astrocytic gliomas is closely related to WHO tumor grade. Within one tumor grade, especially in grade II and III tumors, the clinical course is variable and can hardly be predicted by histological criteria. Neovascularization is a neuropathological hallmark in high grade gliomas and angiogenic factors may play an important role in malignant tumor progression. Therefore, 162 primary astrocytic gliomas (57 astrocytomas WHO grade II, 27 astrocytomas WHO grade III and 78 glioblastomas WHO grade IV) were investigated immunohistochemically for expression of vascular endothelial growth factor (VEGF), which is considered to represent the main angiogenic factor in astrocytic gliomas. Clinical data known to influence prognosis were documented. VEGF expression was found in 21 of 57 astrocytomas WHO grade II (36.8%), in 18 of 27 astrocytomas WHO grade III (66.7%) and in 50 of 78 glioblastomas (64.1%). A strong correlation between VEGF expression and survival was found within the whole study group, however, within one tumor grade no such correlation was obvious. In a multifactorial analysis VEGF expression was not found to be an independent prognostic factor in astrocytic gliomas.