An expanded landscape of human long noncoding RNA
An expanded landscape of human long noncoding RNA
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人类长非编码RNA的扩展景观
DOI：
10.1093/nar/gkz621
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发表时间：
2019-09-05
影响因子：
14.9
通讯作者：
Gao, Ge
中科院分区：
文献类型：
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作者：
Jiang, Shuai;Cheng, Si-Jin;Gao, Ge
长非编码RNA(LncRNAs)是涉及生理和病理的多种基本生物学过程的关键调节因子。通过分析来自正常组织和肿瘤组织的14,166个样本的最大概要，我们用一个高质量的图谱：RefLnc(lncRNA参考目录)显著扩展了人类长非编码RNA的图谱。RefLnc在多种来源的全面注释的支持下，帮助精确定位与性别、年龄或种族相关的275个新的基因间LncRNAs，以及与患者生存、临床分期、肿瘤转移或复发相关的369个新的LncRNA。集成在一个用户友好的在线门户网站中，扩展的人类LncRNAs目录为研究LncRNA在人类生物学和癌症发展中的功能提供了宝贵的资源。
Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development.