Unilateral primary aldosteronism as an independent risk factor for vertebral fracture
Unilateral primary aldosteronism as an independent risk factor for vertebral fracture
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单侧原发性醛固酮增多症是椎体骨折的独立危险因素
DOI：
10.1111/cen.14145
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ogawa Y; Q-AND-A study group
中科院分区：
文献类型：
--
作者：
Yokomoto-Umakoshi M;Sakamoto R;Umakoshi H;Matsuda Y;Nagata H;Fukumoto T;Ogata M;Ogawa Y; Q-AND-A study group
背景已知原发性醛固酮增多症 (PA) 会增加椎体骨折 (VF)，但具体机制仍有待阐明。我们假设 PA 亚型与 VF 相关。目的评估单侧 PA 是否与 VF 患病率相关。设计这是在单个转诊中心进行的回顾性横断面研究。患者我们确定了 210 名高血压患者，其临床数据可用于病例检测结果。 152 名患者通过卡托普利激发试验被诊断为 PA。测量我们根据 PA 亚型测量了 VF 的患病率。结果通过肾上腺静脉采样对 151 名 PA 患者进行了亚型分类。其中，37 名患者患有单侧 PA，76 名患者患有双侧 PA，58 名患者患有非 PA； 39 名 PA 患者未进行亚型分类。 PA 患者的 VF 患病率 (29%, 44/152) 高于非 PA 患者 (12%, 7/58;P=.011)。此外，单侧 PA 的 VF 患病率 (46%, 17/37) 高于双侧 PA (20%, 15/76；P= .021)。双侧 PA 和非 PA 之间 VF 的发生率无显着差异。调整年龄和性别后，单侧 PA 是 VF 的独立危险因素（OR：3.16，95% 置信区间：1.12‐8.92；P=0.017）。在单侧 PA 患者中，1 mg 地塞米松抑制试验后，有 VF 的患者血清皮质醇浓度 (1.32 ± 0.67 g/dL) 高于无 VF 的患者 (0.96 ± 0.33 g/dL；P=.048)。 结论 单侧 PA 是 VF 的独立危险因素。
ContextPrimary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.ObjectiveTo evaluate whether unilateral PA is associated with the prevalence of VF.DesignThis was a retrospective cross‐sectional study in a single referral centre.PatientsWe identified 210 hypertensive patients whose clinical data were available for case‐detection results. One hundred and fifty‐two patients were diagnosed with PA using captopril challenge tests.MeasurementsWe measured the prevalence of VF, according to PA subtype.ResultsOne hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non‐PA; 39 patients with PA were not subtype‐classified. Patients with PA had a higher prevalence of VF (29%, 44/152) than those with non‐PA (12%, 7/58;P= .011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17/37) than bilateral PA (20%, 15/76;P= .021). There was no significant differenceinthe prevalence of VF between bilateral PA and non‐PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12‐8.92;P= .017). Among patients with unilateral PA, serum cortisol concentrations after 1‐mg dexamethasone suppression test were higher in those with VF (1.32 ± 0.67 g/dL) than those without (0.96 ± 0.33 g/dL;P= .048).ConclusionsUnilateral PA is an independent risk factor for VF.
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影响因子：
5.8
作者：
A. Salcuni;V. Carnevale;C. Battista;S. Palmieri;C. Eller-Vainicher;V. Guarnieri;F. Pugliese;G. Guglielmi;G. Desina;S. Minisola;I. Chiodini;A. Scillitani
通讯作者：
A. Salcuni;V. Carnevale;C. Battista;S. Palmieri;C. Eller-Vainicher;V. Guarnieri;F. Pugliese;G. Guglielmi;G. Desina;S. Minisola;I. Chiodini;A. Scillitani
影响因子：
4.1
作者：
Umakoshi H;Tsuiki M;Yokomoto-Umakoshi M;Takeda Y;Takashi Y;Kurihara I;Itoh H;Katabami T;Ichijo T;Wada N;Shibayama Y;Yoshimoto T;Ashida K;Ogawa Y;Kawashima J;Sone M;Inagaki N;Takahashi K;Watanabe M;Matsuda Y;Kobayashi H;Shibata H;Kamemura K;Otsuki M;Fujii Y;Yamamto K;Ogo A;Okamura S;Miyauchi S;Fukuoka T;Izawa S;Yanase T;Hashimoto S;Yamada M;Yoshikawa Y;Kai T;Suzuki T;Kawamura T;Naruse M
通讯作者：
Naruse M
Hisashi Fujita：“杏仁核点燃的猫对一氧化二氮的抗惊厥作用具有急性耐受性。”
DOI：
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发表时间：
--
期刊：
影响因子：
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作者：
通讯作者：
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影响因子：
5.8
作者：
Eastell, Richard;Rosen, Clifford J.;Shoback, Dolores
通讯作者：
Shoback, Dolores
影响因子：
8.3
作者：
Reincke, Martin;Fischer, Evelyn;Endres, Stephan
通讯作者：
Endres, Stephan