Polymorphisms in the Matrilin-1 Gene and Risk of Mandibular Prognathism in Koreans
Polymorphisms in the Matrilin-1 Gene and Risk of Mandibular Prognathism in Koreans
复制标题
DOI：
10.1177/0022034510375962
复制
发表时间：
2010-11-01
影响因子：
7.6
通讯作者：
Kwon, T. G.
中科院分区：
文献类型：
--
作者：
Jang, J. Y.;Park, E. K.;Kwon, T. G.
先前对亚洲人群的连锁分析提出了可能的下颌前突候选基因，如Matrlin-1(软骨基质蛋白)。为探讨Matrlin-1基因单核苷酸多态(SNPs)与下颌前突的关系，我们对164例下颌前突患者和132例正常对照进行了3种序列变异(-158T>；C、7987G>；A、8572C>；T)的研究。结果显示，Matrlin-1基因的8572个TT基因型增加了下颌前突的危险性(OR=9.28，95%CI=1.19，与197.57相似，P
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19 similar to 197.57, P