Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development.
Insulin-like growth factor I and II gene expression in Balb/C mouse liver during postnatal development.
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Balb/C 小鼠肝脏在出生后发育过程中胰岛素样生长因子 I 和 II 基因的表达。
DOI：
10.1159/000243383
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Styne,DM
中科院分区：
文献类型：
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作者：
Singh,JS;Rall,LB;Styne,DM
我们研究了 Balb/C 小鼠肝脏中从 IGF-II 到 IGF-I mRNA 合成的发育转变。 IGF-I mRNA 水平在出生时较低，随着年龄的增长而增加，在断奶时达到峰值，并且 IGF-I 基因表达在青春期再次增加。 IGF-II 表达在出生后早期发育期间很高，但在断奶时变得不可检测。因此，在生命早期，IGF-I mRNA 上升和 IGF-II mRNA 下降存在相互关系。 Northern 分析揭示了 4 个 IGF-I mRNA 转录本，长度范围为 1.1-7.0 kb，其中 1.1 kb 最为突出。发现了 5 个 IGF-II 转录物，长度范围为 1.7-4.0 kb，其中 4.0 kb 最为突出。血清 IGF-I 和 IGF-II 值的模式与肝脏 IGF-I 和 IGF-II mRNA 水平平行。
We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1–7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7–4.0 kb were found, with the 4,0 kb being the most prominent. The pattern of Serum IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.