Antimicrobial Peptides: a New Frontier in Antifungal Therapy.
Antimicrobial Peptides: a New Frontier in Antifungal Therapy.
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DOI：
10.1128/mbio.02123-20
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发表时间：
2020-11-03
期刊：
影响因子：
6.4
通讯作者：
Lorenz MC
中科院分区：
文献类型：
--
作者：
Buda De Cesare G;Cristy SA;Garsin DA;Lorenz MC
人类侵袭性真菌感染通常与高死亡率相关，因此抗真菌药物的选择对患者的结局至关重要。有限的抗真菌药物谱和耐药性的发展是目前抗真菌治疗的主要问题，需要替代策略。抗菌肽（Antimicrobial peptides，AMP）在多种生物体中表达，作为抗微生物感染的第一线防御手段，具有宿主毒性小、耐药率低等特点，已成为开发新型抗真菌治疗药物的潜在候选药物。人类侵袭性真菌感染通常与高死亡率相关，因此抗真菌药物的选择对患者的结局至关重要。有限的抗真菌药物谱和耐药性的发展是目前抗真菌治疗的主要问题，需要替代策略。抗菌肽（Antimicrobial peptides，AMP）在多种生物体中表达，作为抗微生物感染的第一线防御手段，具有宿主毒性小、耐药率低等特点，已成为开发新型抗真菌治疗药物的潜在候选药物。目前的文献大多集中在具有抗菌活性的肽上，但对其抗真菌特性的研究较少。本文综述了抗菌肽的抗真菌作用，包括其在体外和体内的活动，与真菌细胞的生物学反应，当已知的。肽的分类是基于它们的作用模式：虽然大多数AMP通过与膜的相互作用发挥其活性，但已确定其他机制，包括细胞壁抑制和核酸结合。此外，还描述了具有未知作用模式的抗真菌化合物。这些机制的阐明可用于鉴定新的药物靶标，并且可能用作合成具有增加的活性和降低的宿主毒性的新的抗微生物化合物的模板。
Invasive fungal infections in humans are generally associated with high mortality, making the choice of antifungal drug crucial for the outcome of the patient. The limited spectrum of antifungals available and the development of drug resistance represent the main concerns for the current antifungal treatments, requiring alternative strategies. Antimicrobial peptides (AMPs), expressed in several organisms and used as first-line defenses against microbial infections, have emerged as potential candidates for developing new antifungal therapies, characterized by negligible host toxicity and low resistance rates. Invasive fungal infections in humans are generally associated with high mortality, making the choice of antifungal drug crucial for the outcome of the patient. The limited spectrum of antifungals available and the development of drug resistance represent the main concerns for the current antifungal treatments, requiring alternative strategies. Antimicrobial peptides (AMPs), expressed in several organisms and used as first-line defenses against microbial infections, have emerged as potential candidates for developing new antifungal therapies, characterized by negligible host toxicity and low resistance rates. Most of the current literature focuses on peptides with antibacterial activity, but there are fewer studies of their antifungal properties. This review focuses on AMPs with antifungal effects, including their in vitro and in vivo activities, with the biological repercussions on the fungal cells, when known. The classification of the peptides is based on their mode of action: although the majority of AMPs exert their activity through the interaction with membranes, other mechanisms have been identified, including cell wall inhibition and nucleic acid binding. In addition, antifungal compounds with unknown modes of action are also described. The elucidation of such mechanisms can be useful to identify novel drug targets and, possibly, to serve as the templates for the synthesis of new antimicrobial compounds with increased activity and reduced host toxicity.
影响因子：
4.3
作者：
Burkard TR;Rix U;Breitwieser FP;Superti-Furga G;Colinge J
通讯作者：
Colinge J