BOVINE ANTIGENS AND THE FORMATION OF CIRCULATING IMMUNE-COMPLEXES IN SELECTIVE IMMUNOGLOBULIN-A DEFICIENCY
BOVINE ANTIGENS AND THE FORMATION OF CIRCULATING IMMUNE-COMPLEXES IN SELECTIVE IMMUNOGLOBULIN-A DEFICIENCY
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DOI：
10.1172/jci109448
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发表时间：
1979-01-01
影响因子：
15.9
通讯作者：
DAY, NK
中科院分区：
文献类型：
--
作者：
CUNNINGHAMRUNDLES, C;BRANDEIS, WE;DAY, NK
在选择性免疫球蛋白（Ig）A缺乏的个体中，循环免疫复合物的水平显然与牛乳蛋白沉淀抗体的存在密切相关。为了测试牛奶蛋白是否参与免疫复合物的形成，研究了7名iga缺乏个体在摄入牛奶后血清中复合物的出现。在7个实验中，有3个实验中，复合物水平先是下降，然后上升，在120-150分钟达到峰值。在另外3种情况下，有2个络合物峰的形成趋势，第1个峰在喝牛奶后30-60分钟，第2个峰在喝牛奶后120-150分钟。其中一名受试者最近接受了两种不同肿瘤的治疗，其复合物水平稳定，在测试过程中没有变化。在饮用牛奶后，在一个人的血清中发现的复合物的分子量在牛奶测试开始时从bbb19s下降到7-11S，并且在体外逐渐增加牛奶蛋白或牛γ球蛋白的混合物的量，到含有复合物的血清中产生了可检测到的复合物水平的逐渐降低。在一些缺乏IgA的患者中发现的循环免疫复合物可能含有牛乳蛋白，并且这种复合物的分子量可能随抗原摄入而周期性波动。目前尚不清楚慢性循环复合物对这组患者的临床状态有什么影响。
Levels of circulating immune complexes are apparently closely associated with the presence of precipitating antibodies to bovine milk proteins in individuals with selective immunoglobin (Ig)A deficiency. To test whether milk proteins are involved in immune complex formation, sera of 7 IgA-deficient individuals were studied for the appearance of complexes after milk ingestion. In 3 of the 7, an initial fall in the level of complexes was followed by an increasing value, which peaked at 120-150 min. In another 3, there was a tendency toward the formation of 2 peaks of complexes, the 1st at 30-60 min and the 2nd at 120-150 min after drinking milk. One subject, who had had recent treatment for 2 separate neoplasms, had a steady level of complexes that did not change during the course of this test. After drinking milk, the MW of the complexes found in the sera of 1 individual at the start of the milk test fell from > 19S to 7-11S, and in vitro additions of progressively increasing amounts of a mixture of milk proteins or bovine gamma globulin, to sera that contained complexes produced a progressive reduction in the level of complexes detectable. The circulating immune complexes found in some patients who lack IgA probably contain bovine milk proteins and periodic fluctuation of the MW of such complexes, depending upon antigen ingestion, appears likely. It remains uncertain what effect the chronic circulation of complexes has upon the clinical state of this group of patients.