Radical sublobar resection for lung cancer
Radical sublobar resection for lung cancer
复制标题
肺癌根治性亚肺叶切除术
DOI：
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发表时间：
2008
影响因子：
1.2
通讯作者：
M. Okada
中科院分区：
文献类型：
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作者：
M. Okada
肺叶切除术（肺段切除术或楔形切除术）历来不是治疗肺癌的首选策略，仅作为伴有肺功能不良的早期肺癌患者的折衷方案。虽然一些研究认为肺叶切除术后局部复发率较高，预后较差，但大多数其他研究发现，在选定的患者中，肺叶切除术后有希望的结局。然而，即使是现在，当早期小肺癌被发现的频率越来越高，肺叶切除术尚未成为治疗的选择。本综述总结了文献中肺叶下切除术与肺叶切除术的手术结果。目前的证据表明，根治性肺叶切除术应被视为≤2 cm的cT1N0肺癌的替代方案，即使是低风险患者。因此，为开始一系列新的随机对照试验奠定了基础，这些试验可能会给早期发现时代的肺癌手术带来革命性的变化。
Sublobar resection (segmentectomy or wedge resection) has not historically been the strategy of choice for treating lung cancer and is performed only as a compromise for patients with early-stage lung cancer accompanied by poor lung function. Although some studies have advocated higher rates of local recurrence and a poorer prognosis after sublobar resection than after lobectomy, most others have found promising outcomes after sublobar resection in selected patients. Yet even now, when early-stage small lung cancers are being detected with increasing frequency, sublobar resection has yet to become the treatment of choice. This review summarizes surgical outcomes of sublobar resection compared with lobectomy in the literature. Current evidence indicates that radical sublobar resection should be considered as an alternative for cT1N0 lung cancer of ≤2 cm, even in low-risk patients. A foundation is thus established for starting a new series of randomized controlled trials, which could bring about revolutionary changes to surgery for lung cancer in the era of early detection.