Influence of wound fluid on chemotherapy sensitivity in primary breast cancer cells.
Influence of wound fluid on chemotherapy sensitivity in primary breast cancer cells.
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伤口液对原发性乳腺癌细胞化疗敏感性的影响
DOI：
10.18632/oncotarget.11345
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发表时间：
2016-10-04
期刊：
影响因子：
--
通讯作者：
Liu C
中科院分区：
文献类型：
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作者：
Zhang Y;Yan D;Zhang H;Ou X;Zhao Z;Wang D;Liu C
目的应用CD-DST法研究白藜芦醇对乳腺癌患者乳腺癌细胞化疗敏感性的影响。结果在不同的抗癌药物亚组中，与对照组相比，WF处理组的细胞存活率均显著提高。在绝经前、绝经后、T2、N 0、N1、管腔型B和TN患者的所有肿瘤细胞中普遍观察到这种趋势。方法采用CD-DST法检测2014年9月至2015年7月行乳腺癌根治术的21例患者的原代乳腺癌细胞对EPI、CDDP、DOC、VNR、5-FU+LV和PAC等抗癌药物的敏感性。记录乳腺癌细胞的存活率并用于衡量化疗效果。结论手术诱导的WF促进了乳腺癌原代细胞对化疗药物的耐药性，提示手术可能对乳腺癌患者产生不良影响。需要更多的研究来探讨WF中增加化疗药物敏感性的关键因素。
Objective To investigate the effect of WF on chemotherapy sensitivities of primary breast cancer cells from breast cancer patients by using CD-DST. Results In general, the WF-treated cells showed remarkable increase in survival rates as compared to the control cells cultured without WF among different anticancer drug subgroups. This trend was generally observed in all the tumor cells from the premenopausal, postmenopausal, T2, N0, N1, luminal B, and TN patients. Methods The sensitivities of WF-treated primary breast cancer cells, from 21 patients who underwent a radical resection for breast cancer from September 2014 to July 2015, to anticancer drugs: EPI, CDDP, DOC, VNR, 5-FU+LV, and PAC, were obtained using CD-DST. The survival rates of the breast cancer cells were recorded and used to gauge the chemotherapeutic effect. Conclusions Surgery-induced WF promotes the drug resistance of primary breast cancer cells to chemotherapy, suggesting that surgery may have adverse effects on breast cancer patients. More studies are needed to investigate the key factors in WF that enhance the susceptibility to chemotherapy drugs.