Alpha-adrenoceptor mediated feed-back control of sympathetic neurotransmitter secretion in guinea-pig vas deferens.
Alpha-adrenoceptor mediated feed-back control of sympathetic neurotransmitter secretion in guinea-pig vas deferens.
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α-肾上腺素受体介导豚鼠输精管交感神经递质分泌的反馈控制。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
L. Stjärne
中科院分区：
文献类型：
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作者：
L. Stjärne
最近有相当多的证据表明，交感神经在神经冲动传播后分泌去甲肾上腺素（NA）不是一个全有或全无的过程，而是一个分级的、受控制的生理过程。一种控制机制似乎是由前列腺素E（PGE）1的局部形成介导的。因此，交感神经刺激导致大量PGE 2，3的形成和释放。在已知生理发生的浓度下添加外源性PGE严重抑制交感神经递质分泌4 -6。阻断PGE的局部形成增强了神经刺激诱导的NA在几种组织和物种中的分泌7 -10，表明去除了PGE介导的NA分泌的负反馈控制。
CONSIDERABLE recent evidence indicates that the secretion of noradrenaline (NA) from sympathetic nerves, on arrival of the propagated nerve impulse, is not an all-or-none but a graded and controlled physiological process. One control mechanism appears to be mediated by the local formation of prostaglandin E (PGE)1. Thus sympathetic nerve stimulation causes formation and release of large amounts of PGE2,3. Addition of exogenous PGE at concentrations known to occur physiologically severely depresses sympathetic neurotransmitter secretion4–6. Blocking local formation of PGE enhances nerve stimulation induced secretion of NA in several tissues and species7–10, suggesting removal of a PGE-mediated negative feed-back control of NA secretion.