Anxiety and Depression Symptoms as Risk Factors for Non-adherence to Antiretroviral Therapy in Brazil
Anxiety and Depression Symptoms as Risk Factors for Non-adherence to Antiretroviral Therapy in Brazil
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DOI：
10.1007/s10461-008-9435-8
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发表时间：
2010-04-01
影响因子：
4.4
通讯作者：
Remien, Robert H.
中科院分区：
文献类型：
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作者：
Campos, Lorenza Nogueira;Crosland Guimaraes, Mark Drew;Remien, Robert H.
抑郁和焦虑在艾滋病毒感染者中很常见，是不坚持抗逆转录病毒治疗（ART）的最强预测因素之一。这项纵向研究的目的是评估是否焦虑和抑郁的症状是在贝洛奥里藏特，巴西的两个公共转诊中心（n = 293）开始ART患者的非依从性的预测。在开始ART之前，严重焦虑和抑郁症状的患病率分别为12.6%和5.8%。严重焦虑是随访期间不依从ART的预测因子（RH = 1.87; 95%CI = 1.14-3.06），经低教育、失业、最近一个月饮酒和AIDS症状调整后;而注射吸毒史与不依从有边缘统计学意义。这些研究结果表明，在开始ART之前使用简短的筛查程序来评估焦虑和抑郁症状，有助于确定干预措施的个体，以提高依从性和生活质量。
Depression and anxiety are common among HIV-infected people and rank among the strongest predictors of non-adherence to antiretroviral therapy (ART). This longitudinal study aimed to assess whether symptoms of anxiety and depression are predictors of non-adherence among patients initiating ART at two public referral centers (n = 293) in Belo Horizonte, Brazil. Prevalence of severe anxiety and depression symptoms before starting ART was 12.6% and 5.8%, respectively. Severe anxiety was a predictor of non-adherence to ART during follow-up period (RH = 1.87; 95% CI = 1.14-3.06) adjusted for low education, unemployment, alcohol use in the last month and symptoms of AIDS; while a history of injection drug use had borderline statistical significance with non-adherence. These findings suggest that using a brief screening procedure to assess anxiety and depression symptoms before initiating ART help identify individuals for interventions to improve adherence and quality of life.