SKIN TUMOR-PROMOTING ACTIVITY OF BENZOYL PEROXIDE, A WIDELY USED FREE RADICAL-GENERATING COMPOUND
SKIN TUMOR-PROMOTING ACTIVITY OF BENZOYL PEROXIDE, A WIDELY USED FREE RADICAL-GENERATING COMPOUND
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DOI：
10.1126/science.6791284
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
TROSKO, JE
中科院分区：
文献类型：
--
作者：
SLAGA, TJ;KLEINSZANTO, AJP;TROSKO, JE
过氧化苯甲酰是一种广泛使用的产生自由基的化合物，在7，12-二甲基苯并[a]蒽引发后局部应用于小鼠时，可促进乳头状瘤和癌。过氧苯甲酰作为完全致癌物或肿瘤引发剂对皮肤无活性。过氧化苯甲酰的单次局部应用产生了显著的表皮增生，并诱导了大量的深色基底角质形成细胞，其作用与强效肿瘤促进剂12-O-十四烷酰基佛波醇-13-乙酸酯产生的作用相似。过氧化苯甲酰，像其他已知的肿瘤促进剂，也抑制代谢合作（细胞间通讯）在中国仓鼠细胞。建议在使用该化合物和其他产生自由基的化合物时应谨慎。
Benzoyl peroxide, a widely used free radical-generating compound, promoted both papillomas and carcinomas when it was topically applied to mice after 7,12-dimethylbenz[a]anthracene initiation. Benzoyl peroxide was inactive on the skin as a complete carcinogen or as a tumor initiator. A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate. Benzoyl peroxide, like other known tumor promoters, also inhibited metabolic cooperation (intercellular communication) in Chinese hamster cells. Caution is recommended in the use of this and other free radical-generating compounds.