Adverse childhood experiences and deleterious outcomes in adulthood: A consideration of the simultaneous role of genetic and environmental influences in two independent samples from the United States.
Adverse childhood experiences and deleterious outcomes in adulthood: A consideration of the simultaneous role of genetic and environmental influences in two independent samples from the United States.
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DOI：
10.1016/j.chiabu.2018.12.022
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发表时间：
2019-02
影响因子：
4.8
通讯作者：
J. A. Schwartz;E. Wright;B. A. Valgardson
中科院分区：
文献类型：
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作者：
J. A. Schwartz;E. Wright;B. A. Valgardson
背景童年不良经历（Aces）是一个潜在的危险因素。尽管有这些发现，研究也认识到考虑其他来源的遗传和环境的影响，集群内family. Objectives适当控制潜在来源的遗传和家庭内的环境影响和隔离ACE和以下结果之间的关联在成年期的重要性。身体健康，抑郁症状，教育程度，收入水平，酒精问题，参与者和设置来自美国的双胞胎和兄弟姐妹的两个独立样本：美国中年发展（MIDUS）研究（N= 862）和国家青少年至成人健康纵向研究（添加健康;N= 3112）.MethodsSibling比较模型，控制潜在的遗传和家庭内的环境影响的来源，估计检查是否差异暴露于ACE与检查outcomes.ResultsFamilies经历了更多的逆境也经历了更多的有害后果。然而，经历更多逆境的兄弟姐妹并不比他们的同胞兄弟姐妹更容易经历有害的结果。然而，更多的ACE暴露与抑郁症状的增加有关（添加健康）。额外的模型显示，来自同一个家庭的兄弟姐妹之间的相似性源于潜在来源的家庭内的环境影响，而不是传统的ACE measures.ConclusionsConsidering遗传影响和额外的潜在来源的家庭内的影响是至关重要的隔离ACE的影响。目前采用的ACE措施可能无法充分捕获家庭层面环境影响的所有影响来源。
BackgroundAdverse childhood experiences (ACEs) are a potent risk factor. Despite these findings, studies have also recognized the importance of considering additional sources of genetic and environmental influence that cluster within families.ObjectiveTo properly control for latent sources of genetic and within-family environmental influences and isolate the association between ACEs and the following outcomes in adulthood: physical health, depressive symptoms, educational attainment, income attainment, alcohol problems, and antisocial behavior.Participants and SettingTwo independent samples of twins and siblings from the United States: the Midlife Development in the United States (MIDUS) study (N= 862) and the National Longitudinal Study of Adolescent to Adult Health (Add Health;N= 3112).MethodsSibling comparison models, which control for latent sources of genetic and within-family environmental influences, were estimated to examine whether differential exposure to ACEs was associated with the examined outcomes.ResultsFamilies that experienced more adversity also experienced more deleterious outcomes. However, siblings that experienced more adversity were no more likely to experience deleterious outcomes than their co-siblings. However, greater exposure to ACEs was associated with increases in depressive symptoms (Add Health). Additional models revealed that the similarity between siblings from the same family stemmed from latent sources of within-family environmental influences not captured by traditional ACEs measures.ConclusionsConsidering genetic influences and additional latent sources of within-family influences is crucial in isolating the effects of ACEs. Currently employed ACEs measures may not adequately capture the full range of impactful sources of family-level environmental influence.