Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya.
Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya.
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DOI：
10.1007/s10461-015-1213-9
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发表时间：
2016-04
影响因子：
4.4
通讯作者：
Siika AM
中科院分区：
文献类型：
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作者：
Kurth AE;Cleland CM;Chhun N;Sidle JE;Were E;Naanyu V;Emonyi W;Macharia SM;Sang E;Siika AM
我们在肯尼亚西部的一般人群中评估了无监督的口服液（OF）HIV自我检测（HIVST）的性能、准确性和可接受性参数。在一项前瞻性验证设计中，我们招募了240名成年人进行快速OF HIVST，并将结果与工作人员进行的OF和快速手指针刺试验进行比较。所有反应性、不一致和部分阴性结果均采用实验室ELISA进行确认。20名参与者进行自我测试的视频记录。所有参与者完成了工作人员管理的调查之前和之后，艾滋病毒感染者评估的态度对艾滋病毒感染者的可接受性。艾滋病毒感染率为14.6%。239例HIV感染者中有36例无效（15.1%; 95%CI 11.1- 20.1%），男性无效结果的可能性是女性的两倍。HIVST的敏感性为89.7%（95%CI 73- 98%），特异性为98%（95%CI 89- 99%）.虽然灵敏度略低于预期，但对OF HIV自我检测的兴趣明显，可接受性高（94%）。
We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1–20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73–98 %) and specificity was 98 % (95 % CI 89–99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.