Excitatory effects of iontophoretically applied substance P on neurons in the nucleus tractus solitarius of the cat: lack of interaction with opiates and opioids
Excitatory effects of iontophoretically applied substance P on neurons in the nucleus tractus solitarius of the cat: lack of interaction with opiates and opioids
复制标题
离子导入 P 物质对猫孤束核神经元的兴奋作用：与阿片类药物和阿片类药物缺乏相互作用
DOI：
10.1016/0006-8993(84)90502-x
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
M. Denavit‐Saubié
中科院分区：
文献类型：
--
作者：
M. Morin‐Surun;D. Jordan;J. Champagnat;K. Spyer;M. Denavit‐Saubié
研究了P物质（SP）、（d-Pro 2，d-Trp 7，9）-SP和（d-Pro 4，d-Trp 7，9，10）-SP对孤束核（NTS）神经元的作用，这些神经元的组织学定位、对迷走神经或颈动脉窦神经刺激的反应以及它们与中枢呼吸驱动的功能相关性。SP的强有力的和一致的兴奋作用被发现支持其作为一个假定的兴奋性递质在NTS的作用。P物质和谷氨酸（Glu）的影响，区分的相对不敏感性的P物质诱导的兴奋左啡烷和甲硫脑啡肽。
The effects of iontophoretically applied substance P (SP), (d-Pro2,d-Trp7,9)-SP and (d-Pro4,d-Trp7,9,10)-SP were studied on neurons identified by their histological location in the nucleus tractus solitarius (NTS), their response to vagal or carotid sinus nerve stimulation and eventually their functional correlation with the central respiratory drive. Potent and consistent excitatory effects of SP were found supporting its role as a putative excitatory transmitter in the NTS. The effects of SP andl-glutamate (Glu) were differentiated by the relative insensitivity of SP-induced excitations to levorphanol and Met-enkephalin.