The First Analysis and Clinical Evaluation of Native Breast Tissue Using Differential Phase-Contrast Mammography
The First Analysis and Clinical Evaluation of Native Breast Tissue Using Differential Phase-Contrast Mammography
复制标题
DOI：
10.1097/rli.0b013e31822a585f
复制
发表时间：
2011-12-01
影响因子：
6.7
通讯作者：
Hauser, Nik
中科院分区：
文献类型：
--
作者：
Stampanoni, Marco;Wang, Zhentian;Hauser, Nik
目的：已知相衬和基于散射的X射线成像为传统的基于吸收的方法提供额外的和补充的信息，因此具有在医学诊断中发挥关键作用的潜力。我们报告的第一次乳房X线摄影调查5本地，也就是说，新鲜解剖，乳房进行了光栅干涉仪和传统的X射线管源。本研究中有4例患者经组织病理学证实患有浸润性乳腺癌。一名男性患者，没有任何恶性形成内切除乳腺癌的存在下，被列为对照speciments.Materials和方法：我们使用了Talbot-Lau光栅设置安装在一个传统的，低亮度的X射线源;干涉仪操作在第五塔尔博特距离，在管电压为40 kVp，平均能量为28千电子伏，并在25毫安的电流。该设备同时记录吸收，微分相位和小角度散射信号从天然乳腺组织。然后将这些量组合成新的彩色和高频增强的射线照相图像。术前图像（常规乳腺X线摄影，超声检查和磁共振成像）支持的结果和临床相关性进行了verified.Results：我们的方法产生互补的，否则无法访问的信息的电子密度分布和小角度散射功率的样品在微观尺度上。这些信息可以用来回答潜在的临床相关的，但尚未解决的问题，如明确辨别恶性和癌前病变和术后疤痕和区分癌症侵袭区域内的健康tissue.Conclusions：我们提出了第一个离体图像的新鲜，原生乳腺组织从乳房切除术标本使用光栅干涉。与传统的乳房X线摄影相比，这种技术提高了诊断能力，特别是在辨别正常乳腺组织内恶性转化的类型及其宽度时。这些有希望的结果推进我们的最终目标，在临床环境中使用人体光栅干涉测量。
Objectives: Phase-contrast and scattering-based x-ray imaging are known to provide additional and complementary information to conventional, absorption-based methods, and therefore have the potential to play a crucial role in medical diagnostics. We report on the first mammographic investigation of 5 native, that is, freshly dissected, breasts carried out with a grating interferometer and a conventional x-ray tube source. Four patients in this study had histopathologically proven invasive breast cancer. One male patient, without the presence of any malignant formations within the resected breast, was included as a control specimen.Materials and Methods: We used a Talbot-Lau grating setup installed on a conventional, low-brilliance x-ray source; the interferometer operated at the fifth Talbot distance, at a tube voltage of 40 kVp with mean energy of 28 keV, and at a current of 25 mA. The device simultaneously recorded absorption, differential phase and small-angle scattering signals from the native breast tissue. These quantities were then combined into novel color- and high-frequency-enhanced radiographic images. Presurgical images (conventional mammography, ultrasonography, and magnetic resonance imaging) supported the findings and clinical relevance was verified.Results: Our approach yields complementary and otherwise inaccessible information on the electron density distribution and the small-angle scattering power of the sample at the microscopic scale. This information can be used to potentially answer clinically relevant, yet unresolved questions such as unequivocally discerning between malignant and premalignant changes and postoperative scars and distinguishing cancer-invaded regions within healthy tissue.Conclusions: We present the first ex vivo images of fresh, native breast tissue obtained from mastectomy specimens using grating interferometry. This technique yields improved diagnostic capabilities when compared with conventional mammography, especially when discerning the type of malignant conversions and their breadth within normal breast tissue. These promising results advance us toward the ultimate goal, using grating interferometry in vivo on humans in a clinical setting.