SPEED: a molecular-evolution-based database of mammalian orthologous groups
SPEED: a molecular-evolution-based database of mammalian orthologous groups
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DOI：
10.1093/bioinformatics/btl471
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发表时间：
2006-11-15
期刊：
影响因子：
5.8
通讯作者：
Wyckoff, Gerald J.
中科院分区：
文献类型：
--
作者：
Vallender, Eric J.;Paschall, Justin E.;Wyckoff, Gerald J.
动机：丰富的核苷酸序列信息已经扩大了对分子进化的研究范围;然而，由于工具不足，全基因组分析的全部潜力尚未实现。在这里，我们提出了第一个工具包，以帮助多学科的高通量analysis.Summary：SPEED的创建整合分子进化数据与现有的遗传资源，并提供了一个简单的用户界面，以17 352 orthopathic基因组，包含代表从8个哺乳动物物种和鸟类outgroup.Availability：见http://bioinfobase.umkc.edu/speed/for访问联系：wyckoffg@umkc. edu补充信息：一个更大版本的数据模型和网站地图可在线。
Motivation: The abundance of nucleotide sequence information available has expanded horizons of inquiry for molecular evolution; however, the full potential of whole-genome analysis has not been realized because of inadequate tools. Here, we present one of the first toolkits to aid multidisciplinary high-throughput analysis.Summary: SPEED was created to integrate molecular evolutionary data with existing genetic resources and provide a straightforward user interface to 17 352 orthologous gene groups, containing representatives from eight mammalian species and an avian outgroup.Availability: See http://bioinfobase.umkc.edu/speed/for accessContact: wyckoffg@umkc.eduSupplementary information: A larger version of the data model and a site map are available online.