Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging.
Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging.
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DOI：
10.1002/stem.1294
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发表时间：
2013-03
期刊：
影响因子：
5.2
通讯作者：
Pignolo, Robert J.
中科院分区：
文献类型：
--
作者：
Singh, Lakshman;Brennan, Tracy A.;Kim, Jung-Hoon;Egan, Kevin P.;Mcmillan, Emily A.;Chen, Qijun;Hankenson, Kurt D.;Zhang, Yi;Emerson, Stephen G.;Johnson, F. Brad;Pignolo, Robert J.
Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important cellular mechanism which may in part explain osteoblast dysfunction that occurs with aging is senescence of mesenchymal progenitor cells (MPCs). In the telomere-based Wrn−/−Terc−/− model of accelerated aging, the osteoporotic phenotype of these mice is also associated with a major decline in MPC differentiation into osteoblasts. To investigate the role of MPC aging as a cell-autonomous mechanism in senile bone loss, transplantation of young wild-type whole bone marrow into Wrn−/−Terc−/− mutants was performed and the ability of engrafted cells to differentiate into cells of the osteoblast lineage was assessed. We found that whole bone marrow transplantation (BMT) in Wrn−/−Terc−/− mice resulted in functional engraftment of MPCs up to 42 weeks, which was accompanied by a survival advantage, as well as delays in microarchitectural features of skeletal aging.
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DOI：
10.1073/pnas.1036475100
发表时间：
2003-05-13
影响因子：
11.1
作者：
Bonyadi, M;Waldman, SD;Stanford, WL
通讯作者：
Stanford, WL
影响因子：
7.8
作者：
Pignolo, Robert J.;Suda, Robin K.;Johnson, F. Brad
通讯作者：
Johnson, F. Brad
影响因子：
11.2
作者：
Bernardo, Maria Ester;Zaffaroni, Nadia;Locatelli, Franco
通讯作者：
Locatelli, Franco
DOI：
10.1093/gerona/60.1.10
发表时间：
2005-01-01
影响因子：
5.1
作者：
Hofer, AC;Tran, RT;Lewis, M
通讯作者：
Lewis, M
影响因子：
82.9
作者：
Horwitz, EM;Prockop, DJ;Brenner, MK
通讯作者：
Brenner, MK