RETROSPECTIVE STUDY OF THE TOXICITY OF PREPARATIONS OF VANCOMYCIN FROM 1974 TO 1981
RETROSPECTIVE STUDY OF THE TOXICITY OF PREPARATIONS OF VANCOMYCIN FROM 1974 TO 1981
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DOI：
10.1128/aac.23.1.138
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发表时间：
1983-01-01
影响因子：
4.9
通讯作者：
MOELLERING, RC
中科院分区：
文献类型：
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作者：
FARBER, BF;MOELLERING, RC
对接受100个疗程静脉注射万古霉素治疗的98例患者进行了回顾性图表审查，以更好地确定其毒性。大多数患者被诊断为金黄色葡萄球菌或葡萄球菌。表皮感染未观察到听觉毒性;仅1-3%的受试者发生发热和皮疹。在13%的病例中观察到静脉炎，2%的病例需要停止治疗。治疗并发中性粒细胞减少症（多形核白细胞计数，≤1000个细胞/cm 3），但迅速可逆。在接受万古霉素单药治疗的受试者中，肾毒性不常见（5%）且可逆，即使继续治疗;接受万古霉素与氨基糖苷类药物联合治疗的患者中，35%的患者血清肌酐显著升高。虽然这种高发生率可能是由于选择的患者人群或单独使用氨基糖苷类药物治疗所致，但应考虑万古霉素和氨基糖苷类药物之间存在累加毒性的可能性。
A retrospective chart review of 98 patients treated with 100 courses of i.v. vancomycin was undertaken to better define its toxicity. Most of the patients carried diagnoses of Staphylococcus aureus or S. epidermidis infection. Auditory toxicity was not seen; fever and rash occurred in only 1-3% of the subjects. Phlebitis was noted in 13% of the cases and required discontinuation of therapy in 2%. Therapy was complicated by neutropenia (polymorphonuclear leukocyte count, .ltoreq. 1000 cells/cm3) in 2% of the patients but was rapidly reversible. Nephrotoxicity was uncommon (5%) and reversible in subjects receiving vancomycin alone, even when the therapy was continued; 35% of the patients receiving vancomycin with an aminoglycoside developed significant elevations in serum creatinine. Although this high incidence may have been due to the patient population selected or to the aminoglycoside therapy alone, the possibility of additive toxicity between vancomycin and the aminoglycosides should be considered.