The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood
The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood
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DOI：
10.1111/j.1530-0277.2007.00534.x
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发表时间：
2007-12-01
影响因子：
3.2
通讯作者：
Graham, Danielle L.
中科院分区：
文献类型：
--
作者：
Diaz-Granados, Jaime L.;Graham, Danielle L.
背景：青少年中酗酒现象很普遍。流行病学研究表明，青少年发育期间酗酒可能会导致长期变化，例如成年后对酒精相关问题的易感性增加。实验室研究结果表明，与成年期相比，青少年发育期的酒精暴露可能会对随后对酒精的神经行为反应产生不同的影响。本研究旨在检查青春期发育期间连续与间歇性乙醇暴露是否会改变成年 C3H 小鼠对乙醇的厌恶特性。方法：将青春期 (PD28) 雄性 C3H 小鼠暴露于连续或间歇性乙醇蒸气 64 小时。作为比较，成年 (PD70) C3H 小鼠也暴露于连续或间歇性乙醇蒸气 64 小时。乙醇暴露六周后，使用 1 种试验、1 种风味味觉调节程序对预先暴露于乙醇的动物和未接触过乙醇的动物进行味觉厌恶调节。结果：与对照动物相比，青春期期间的乙醇暴露显着减弱了随后的乙醇诱导的条件性味觉厌恶。与未接触过乙醇的成年动物相比，在青春期长期接触乙醇蒸汽的成年动物对乙醇配对味道的厌恶程度较低。青春期期间间歇性接触乙醇蒸气会产生更大的衰减。结论：青春期期间乙醇暴露会导致长期的神经行为变化，从而减轻成年后对乙醇的条件性厌恶。有人认为，这种与年龄相关的影响可能是酒精相关问题的易感性增加的基础，而酒精相关问题与酗酒的发病年龄呈负相关。
Background: Alcohol abuse among adolescents is prevalent. Epidemiological studies suggest that alcohol abuse during the adolescent developmental period may result in long-term changes such as an increased susceptibility to alcohol-related problems in adulthood. Laboratory findings suggest that alcohol exposure during the adolescent developmental period, as compared with adulthood, may differentially impact subsequent neurobehavioral responses to alcohol. The present study was designed to examine whether ethanol exposure, continuous versus intermittent, during the adolescent developmental period would alter the aversive properties of ethanol in adult C3H mice.Methods: Periadolescent (PD28) male C3H mice were exposed to 64 hours of continuous or intermittent ethanol vapor. As a comparison, adult (PD70) C3H mice were also exposed to 64 hours of continuous or intermittent ethanol vapor. Six weeks after ethanol exposure, taste aversion conditioning was carried out on both ethanol pre-exposed and ethanol-naive animals using a 1-trial, 1-flavor taste-conditioning procedure.Results: Ethanol exposure during the periadolescent period significantly attenuated a subsequent ethanol-induced conditioned taste aversion, as compared with control animals. Adult animals exposed to chronic ethanol vapor during adolescence showed less of an aversion to an ethanol-paired flavor than ethanol-naive adults. Intermittent exposure to ethanol vapor during periadolescence produced a greater attenuation.Conclusion: It is suggested that ethanol exposure during the periadolescent period results in long-term neurobehavioral changes, which lessen a conditioned aversion to ethanol in adulthood. It is suggested that this age-related effect may underlie the increased susceptibility to alcohol-related problems which is negatively correlated with the age of onset for alcohol abuse.