Weight Loss and Regain and Effects on Body Composition: The Health, Aging, and Body Composition Study
Weight Loss and Regain and Effects on Body Composition: The Health, Aging, and Body Composition Study
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DOI：
10.1093/gerona/glp042
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发表时间：
2010-01-01
影响因子：
5.1
通讯作者：
Newman, Anne B.
中科院分区：
文献类型：
--
作者：
Lee, Jung Sun;Visser, Marjolein;Newman, Anne B.
随着体重的变化，老年人相对于脂肪量更不能够保持瘦体重。老年人体重减轻和恢复的周期可能会加速肌肉减少症。我们研究了在健康、衰老和身体成分研究中，经历体重减轻和恢复的老年人在减肥期间的瘦体重减轻是否比在体重恢复期间的瘦体重增加更大，因此与那些保持体重的人相比，瘦体重的净减少总体上更大。（54%的女性，38%的黑人）与性别和种族匹配的体重稳定的个体在体重循环期间。体重周期定义为体重减轻3%或以上，体重恢复在基线体重的+/- 3%范围内，持续2年。男性和女性在体重减轻和恢复后的总体重均显着降低。从比例上讲，在减肥期间失去的瘦体重比在体重恢复期间增加的瘦体重要多，尤其是在男性中。体重恢复后，男性的瘦体重仅略低于稳定组，这在统计学上并不显著，尽管未能完全恢复总体重解释了体重周期后瘦体重的大部分不足。这些数据表明，即使体重恢复，体重减轻也可能导致老年男性瘦体重的净减少，但需要进一步研究。
Older adults are less able to conserve lean mass relative to fat mass with weight change. A cycle of weight loss and regain in an older individual could accelerate sarcopenia. We examined whether older adults experiencing weight loss and regain would show a greater loss of lean mass during a weight-loss period than gain in lean mass during the weight-regain period, thus have overall a greater net loss of lean mass compared with those who maintained weight in the Health, Aging, and Body Composition Study.We compared the body composition change in 147 older weight changers (54% women, 38% black) with the gender- and race-matched weight-stable individuals over the weight-cycling period. A weight cycle was defined as weight loss of 3% or more with regain of within +/- 3% of baseline weight for a period of 2 years.Both men and women showed significantly lower total body mass after the weight loss and regain. Proportionally, more lean mass was lost during the weight-loss period than was gained during the weight-regain period, especially in men. After weight regain, men showed only a slightly lower lean mass than the stable group, and this was not statistically significant, although the failure to fully regain total weight explained most of the deficit in lean mass after the weight cycle.These data suggest that weight loss even with regain may contribute to a net loss of lean mass in older men but warrant further studies.