Enhanced acute-phase response and oxidative stress in older adults with type II diabetes
Enhanced acute-phase response and oxidative stress in older adults with type II diabetes
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DOI：
10.1055/s-2007-978662
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发表时间：
2000-10-01
影响因子：
2.2
通讯作者：
Montiel, C
中科院分区：
文献类型：
--
作者：
Arnalich, F;Hernanz, A;Montiel, C
目的：测试氧化应激是否可以促进老年 II 型糖尿病患者的全身急性期反应。设计和方法：在一组 30 名血糖控制不佳的老年糖尿病患者中，测量了以硫代巴比妥酸反应物质 (TBARS) 测量的血清过氧化物脂质水平； C反应蛋白（CRP）；在基线以及治疗干预 2 个月和 3 个月后对白细胞介素 (IL)-6 及其可溶形式的受体 (sIL-6R) 进行评估。三十名无症状、未经治疗、空腹血糖异常但其他方面健康、年龄、性别和体重相似的个体作为对照组。结果：基线时血糖 (8.83+/-0.67 mmol/l)、HbA(1)C (8.66+/-0.59%)。糖尿病患者的 TEARS (8.68+/-1.21 mu mol/l)、CRP (16.05+/-3.81 mg/l) IL-6 (5.39+/-1.25 pg/ml) 和 sIL-6R (1425+/-492 pg/ml) 显着高于无症状高血糖个体 (p
Objective: To test whether oxidative stress could promote a systemic acute-phase response in elderly patients with type II diabetes. Design and Methods: In a group of 30 older diabetic patients with poor glycemic control, serum levels of lipid per oxides, measured as thiobarbituric acid-reacting substances (TBARS); C-reactive protein (CRP); interleukin (IL)-6 and the soluble form of its receptor (sIL-6R), were evaluated at baseline and after 2 and 3 months of therapeutic intervention. Thirty asymptomatic, untreated individuals with abnormal fasting glycemia, but otherwise healthy status, of similar age, sex, and weight served as control group. Results: At baseline, glycemia (8.83+/-0.67 mmol/l), HbA(1)C (8.66+/-0.59%). TEARS (8.68+/-1.21 mu mol/l), CRP (16.05+/-3.81 mg/l) IL-6 (5.39+/-1.25 pg/ml) and sIL-6R (1425+/-492 pg/ml) were significantly higher in diabetic patients than in asymptomatic hyperglycemic individuals (p