On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer.
On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer.
复制标题
化学在生物制品生产中的新兴作用：合成基于双域岩藻糖基 GM1 的疫苗，用于治疗小细胞肺癌。
DOI：
10.1021/jo900918m
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Danishefsky,SamuelJ
中科院分区：
文献类型：
--
作者：
Nagorny,Pavel;Kim,WooHan;Wan,Qian;Lee,Dongjoo;Danishefsky,SamuelJ
The synthesis of the novel small cell lung cancer (SCLC) fucosyl GM1-based vaccine construct, featuring insertion of the HLA-DR binding 15 amino acid sequence derived fromPlasmodium falciparum, is described. The resultant glycopeptide has been synthesized in an efficient manner. Finally, successful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparation of the vaccine.
