Gut microbiome status of urban and rural Filipino adults in relation to diet and metabolic disorders
Gut microbiome status of urban and rural Filipino adults in relation to diet and metabolic disorders
复制标题
菲律宾城乡成年人肠道微生物群状况与饮食和代谢紊乱的关系
DOI：
10.1093/femsle/fnab149
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发表时间：
2021
影响因子：
2.1
通讯作者：
Nakayama Jiro
中科院分区：
文献类型：
--
作者：
Watanabe Mai;Sianoya Abraham;Mishima Riko;Therdtatha Phatthanaphong;Rodriguez Abigail;Ramos Donna Christene;Lee Yuan Kun;Dalmacio Leslie Michelle;Nakayama Jiro
在这里，我们的目标是了解菲律宾成年人肠道微生物组的状况与他们的饮食和代谢状态的关系。与农村阿尔拜（n= 67）相比，生活在马尼拉城市的受试者（n= 25）的肠道微生物组更多地被梭菌目定殖，这与宿主碳水化合物消耗呈负相关。使用92名受试者的属组成进行的主成分分析表明了四种微生物组类型：一个由普雷沃氏菌属驱动的组，其与高大米消耗相关并且主要由健康的阿尔拜受试者组成，一个由梭菌属驱动的组，其包含来自马尼拉和阿尔拜的许多2型糖尿病（T2D）受试者，这些受试者显示出与粪中肠杆菌减少相关的较低丁酸盐水平，而另外两种类型显示出类似于乳酸杆菌和双歧杆菌的微生物群过度生长，T2D和肥胖受试者的比例较高。多因素Logistic回归分析提示，高能量摄入和韦荣球菌属Dialister和Megasphaera是T2D的危险因素，而Prevotella和M.抗T2D因子。总之，低碳水化合物饮食重构了Prevotella驱动的肠道微生物组，这可能使菲律宾人在高能量饮食中易患T2D。
Here, we aim to understand the condition of the gut microbiome of Filipino adults in relation to their diet and metabolic status. Compared to rural Albay (n= 67), the gut microbiome of subjects living in urban Manila (n= 25) was more colonized by the order Clostridiales, which was negatively correlated with host carbohydrate consumption. Principal component analysis using the genus composition of the 92 total subjects indicated four microbiome types: one type driven byPrevotella, which was associated with high rice consumption and mainly consisted of healthy Albay subjects, one Clostridiales-driven group containing a number of type 2 diabetes mellitus (T2D) subjects from both Manila and Albay who showed lower butyrate levels in association with a decrease inMediterraneibacter faecis, and the other two types showing dysbiosis-like microbiomes withLactobacillusandBifidobacteriumovergrowth, with a high ratio of T2D and obese subjects. Multivariate logistic regression analysis suggested high dietary energy intake, and twoVeillonellaeaegenera,DialisterandMegasphaera, as T2D risk factors, whilePrevotellaandM. faecisas anti-T2D factors. In conclusion, low-carbohydrate diets restructured thePrevotella-driven gut microbiome, which may predispose Filipino people with high energy diet to T2D.