The cardiomyocyte circadian clock: emerging roles in health and disease.
The cardiomyocyte circadian clock: emerging roles in health and disease.
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DOI：
10.1161/circresaha.109.209957
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发表时间：
2010-03-05
影响因子：
20.1
通讯作者：
Young ME
中科院分区：
文献类型：
--
作者：
Durgan DJ;Young ME
昼夜节律失调与肥胖、糖尿病和心血管疾病的发展有关。生物体与其环境的时间依赖性同步由生物钟介导。这种细胞自主机制已经在所有心血管相关细胞类型中被鉴定，包括心肌细胞。最近的分子和遗传学研究表明，心肌细胞生物钟影响多个心肌过程，包括转录，信号传导，生长，代谢和收缩功能。随着对其生理作用的认识，最近在动物模型中，心肌细胞生物钟与心脏病的发病机制有关，这些心脏病是对不利应激（如缺血/再灌注）的反应。因此，本文综述的目的是强调心肌细胞昼夜节律钟在心肌生理学和病理生理学（即，健康与疾病）。
Circadian misalignment has been implicated in the development of obesity, diabetes mellitus, and cardiovascular disease. Time-of-day-dependent synchronization of organisms with their environment is mediated by circadian clocks. This cell autonomous mechanism has been identified within all cardiovascular-relevant cell types, including cardiomyocytes. Recent molecular- and genetic- based studies suggest that the cardiomyocyte circadian clock influences multiple myocardial processes, including transcription, signaling, growth, metabolism, and contractile function. Following an appreciation of its physiological roles, the cardiomyocyte circadian clock has recently been linked to the pathogenesis of heart disease in response to adverse stresses, such as ischemia/reperfusion, in animal models. The purpose of this review is therefore to highlight recent advances regarding the roles of the cardiomyocyte circadian clock in both myocardial physiology and pathophysiology (i.e., health and disease).