Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM
Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM
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DOI：
10.1016/j.bbrc.2008.07.065
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发表时间：
2008-09-26
影响因子：
3.1
通讯作者：
Kato, Takeo
中科院分区：
文献类型：
--
作者：
Daimon, Makoto;Sato, Hidenori;Kato, Takeo
在日本人群（n（M/W）：2956（1335/1621）：年龄：63.0 ± 10.2岁）中，研究G蛋白β 3亚基（GNB 3）基因的C825 T多态性（rs 5443）和8个相邻单核苷酸多态性（SNP）与糖尿病的相关性。空腹血糖（FPG）水平与C825 T多态性和两个侧翼SNP（rs 2301339和rs 5446）显著相关（分别为p = 0.002、0.001和0.008）。一项使用多元逻辑回归分析的C825 T多态性与糖尿病的病例对照相关性研究显示，基因型TT + TC与年龄、性别和BMI无关，优势比为0.62（p = 0.008）。然后检查盐消耗对该协会的影响（n = 1635）。FPG水平与C825 T多态性仅在低盐摄入的受试者中显著相关（
The associations of the C825T polymorphism (rs5443) of the G-protein beta 3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621): age: 63.0 +/- 10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p = 0.002, 0.001, and 0.008, respectively). A case-control association Study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT + TC with an odds ratio of 0.62 (p = 0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n = 1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (