Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction.
Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction.
复制标题
加压素对大鼠出血的反应：缺氧和限水的影响。
DOI：
10.1111/j.1440-1681.1991.tb01387.x
复制
发表时间：
1991
影响因子：
2.9
通讯作者：
Jankowski,BM
中科院分区：
文献类型：
--
作者：
Raff,H;Rossing,MH;Doepker,SK;Griffen,SC;Jankowski,BM
1. The aim of the present study was to determine the effect of water restriction and/or hypoxia on the vasopressin response to haemorrhage in conscious rats.2. Male, Long‐Evans rats (n= 39) were prepared with chronically indwelling femoral artery and vein catheters and exposed to 24 h of one of the following: normoxia withad libdrinking water (N + W); normoxia with water restriction (N – W); hypoxia withad libdrinking water (H + W); and hypoxia with water restriction (H – W). At the end of 24 h, a 15 mL/kg arterial haemorrhage was performed.3. Water restricted rats had elevated pre‐haemorrhage vasopressin levels. Haemorrhage induced an increase in vasopressin in all groups. Water restriction (N – W) or hypoxia (H + W) each augmented the vasopressin response to haemorrhage. However, the combination of hypoxia and water restriction (H – W) failed to augment the vasopressin response to haemorrhage as compared to normoxic, water replete (N + W) rats.4. Hypoxia or water restrictionper seaugment the vasopressin response to haemorrhage. This augmented vasopressin response to haemorrhage is not maintained when hypoxia and water restriction are combined.
