Long-lasting potentiation and depression without presynaptic activity.
Long-lasting potentiation and depression without presynaptic activity.
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DOI：
10.1152/jn.1996.75.5.2157
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发表时间：
1996-05
影响因子：
2.5
通讯作者：
Dorine Neveu;Robert S. Zucker
中科院分区：
文献类型：
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作者：
Dorine Neveu;Robert S. Zucker
1.长时程增强（LTP）和长时程抑制（LTD）需要突触后CA 1锥体神经元胞内Ca 2+浓度（[Ca 2 +]i）升高以激活Ca依赖的生化过程。[Ca 2 +]i的升高是诱导LTP和LTD的必要触发因素，但尚不清楚它们的诱导或表达是否需要同时的突触前活动。2.我们使用笼状Ca ~（2+）化合物nitr-5的光解来升高突触后[Ca ~（2+）]i。长持续增强（LLP）和长持续抑制（LLD）的突触前活动的情况下获得。3.由于LLP和LLD与突触前刺激诱导的LTP和LTD具有共同的特征，因此这些结果表明突触后CA 1锥体神经元中[Ca 2 +]i的升高对于LTP和LTD的诱导和表达是必要和充分的，并且不需要同时的突触前活动。
1. Long-term potentiation (LTP) and long-term depression (LTD) require a rise in intracellular Ca2+ concentration ([Ca2+]i) in the postsynaptic CA1 pyramidal neuron to activate Ca-dependent biochemical processes. This rise in [Ca2+]i is a necessary trigger for the induction of LTP and LTD, but it is unclear if concurrent presynaptic activity is required for their induction or expression. 2. We used photolysis of the caged-Ca2+ compound nitr-5 to elevate postsynaptic [Ca2+]i. Long-lasting potentiation (LLP) and long-lasting depression (LLD) were obtained in the absence of presynaptic activity. 3. Because LLP and LLD share common features with LTP and LTD induced by presynaptic stimulation these results show that a rise in [Ca2+]i in the postsynaptic CA1 pyramidal neurons is necessary and sufficient for the induction and expression of LTP and LTD, and that concurrent presynaptic activity is not required.