Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids
Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids
复制标题
通过 Pd 催化 3-碘氮杂环丁烷与芳基硼酸的迁移/偶联合成 2-芳基氮杂环丁烷
DOI：
10.1021/acs.orglett.2c02152
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhenhua Gu
中科院分区：
文献类型：
--
作者：
Han Yang;Zhen Chen;Wenjing Guo;Zhenhua Gu
报道了钯催化的3-碘氮杂环丁烷与非杂芳基硼酸的交叉偶联反应。[1，1 '-联苯基-2-基二环己基膦配体使有利于形成2-芳基氮杂环丁烷的反应成为可能。对照实验表明，该反应可以通过钯-氢化物/二氢氮杂化合物络合物或游离二氢氮杂化合物中间体进行，然后进行氢化钯化。
A palladium-catalyzed cross-coupling of 3-iodoazetidines and nonheteroaryl boronic acids was reported. The [1,1'-biphenyl-2-yldicyclohexylphosphane ligand enabled the reaction that favored the formation of 2-aryl azetidines. The control experiments indicated that the reaction can proceed through either a palladium-hydride/dihydroazete complex or free dihydroazete intermediate followed by hydropalladation.