Transformation of C3H/10T1/2 CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester
Transformation of C3H/10T1/2 CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester
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紫外线照射和佛波酯对 C3H/10T1/2 CL8 小鼠胚胎成纤维细胞的转化
DOI：
10.1038/260710a0
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发表时间：
1976
期刊：
影响因子：
64.8
通讯作者：
C. Heidelberger
中科院分区：
文献类型：
--
作者：
S. Mondal;C. Heidelberger
紫外线是人类皮肤癌的主要诱因，反复暴露于IT1-5会在大鼠和小鼠的皮肤中诱发乳头状瘤和恶性肿瘤。Pound6报道，虽然小鼠皮肤一次短暂暴露在紫外线下不会引起任何肿瘤，但当一次暴露之后反复使用巴豆油时，会诱发许多肿瘤。因此，紫外线在皮肤肿瘤发生的两阶段过程中起到了启动作用。7、8.X射线可诱导第9、10代细胞发生致癌转化，已有关于紫外线对仓鼠胚胎细胞转化的初步报道。
ULTRAVIOLET light is the major cause of human skin cancer, and papillomas and malignant carcinomas have been induced in the skins of rats and mice by repeated exposure to it1–5. Pound6 reported that although a single short exposure of mouse skin to ultraviolet light did not induce any tumours, when the single exposure was followed by repeated applications of croton oil, many tumours were induced. Thus ultraviolet light acted as an initiator in the two-stage process of skin tumour development7,8. X rays can induce oncogenic transformation of cells in culture9,10, and a preliminary report has appeared on the transformation of hamster embryo cells by ultraviolet light11.