Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
复制标题
DOI：
10.1073/pnas.051626798
复制
发表时间：
2001-03-13
影响因子：
11.1
通讯作者：
Tuszynski, MH
中科院分区：
文献类型：
--
作者：
Weidner, N;Ner, A;Tuszynski, MH
尽管人们认为成年哺乳动物脊髓损伤后几乎没有恢复，但事实上，人类脊髓损伤后通常会出现显著的自发性功能改善。为了研究自发恢复的潜在机制，在成年大鼠的颈髓喙侧或延髓尾侧对皮质脊髓运动通路的确定成分进行了损伤。背侧皮质脊髓运动通路，其中包含超过95%的所有皮质脊髓轴突的完全病变后，自发发芽从腹侧皮质脊髓束发生到内侧运动神经元池在颈脊髓，这发芽是由功能恢复。背侧和腹侧皮质脊髓束成分的联合损伤消除了发芽和功能恢复。此外，如果背侧皮质脊髓束损伤5周后又发生腹侧皮质脊髓束损伤，功能恢复也会消失。我们发现，广泛的自发性结构可塑性作为一种机制，与功能恢复的运动系统在成年中枢神经系统。实验性增强自发可塑性可能有助于促进成年中枢神经系统损伤后的进一步恢复。
Although it is believed that little recovery occurs after adult mammalian spinal cord injury, in fact significant spontaneous functional improvement commonly occurs after spinal cord injury in humans. To investigate potential mechanisms underlying spontaneous recovery, lesions of defined components of the corticospinal motor pathway were made in adult rats in the rostral cervical spinal cord or caudal medulla. Following complete lesions of the dorsal corticospinal motor pathway, which contains more than 95% of all corticospinal axons, spontaneous sprouting from the ventral corticospinal tract occurred onto medial motoneuron pools in the cervical spinal cord; this sprouting was paralleled by functional recovery. Combined lesions of both dorsal and ventral corticospinal tract components eliminated sprouting and functional recovery. In addition, functional recovery was also abolished if dorsal corticospinal tract lesions were followed 5 weeks later by ventral corticospinal tract lesions. We found extensive spontaneous structural plasticity as a mechanism correlating with functional recovery in motor systems in the adult central nervous system. Experimental enhancement of spontaneous plasticity may be useful to promote further recovery after adult central nervous system injury.