Flow-induced vasodilation of the human brachial artery is impaired in patients
Flow-induced vasodilation of the human brachial artery is impaired in patients
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DOI：
10.1016/s0002-9149(96)00597-8
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发表时间：
1996-12-01
影响因子：
2.8
通讯作者：
Creager, MA
中科院分区：
文献类型：
--
作者：
Lieberman, EH;Gerhard, MD;Creager, MA
Z本研究的目的是确定异常血流导致的内皮依赖性血管扩张是否能识别年轻的冠心病(CAD)患者。应用高分辨率超声检测14例青年冠心病患者和11例年龄相匹配的健康男性志愿者外周管道血管--臂动脉的血管反应性，通过测量反应性充血引起的血流增加时肱动脉内径的变化来确定内皮依赖性的血管扩张。舌下含服硝酸甘油评价非内皮依赖性血管扩张功能。为了确定血管内皮细胞介导的血管扩张是否是由内皮源性一氧化氮介导的，我们测量了反应性充血时、一氧化氮合酶拮抗剂N-G-单甲基-L-精氨酸(L-NMMA)治疗前和治疗期间的肱动脉内径。并于给药前、后动脉内注入乙酰胆碱和硝普钠时测量肱动脉内径。冠心病组血流诱导的血管扩张低于健康志愿者(1.3+/-1.1%vs6.2+/-0.7%，p
zThe objective of this study was to determine whether abnormal flow-induced endothelium-dependent vasodilation in the brachial artery identifies young patients with coronary artery disease (CAD). High-resolution ultrasonography was used to measure vascular reactivity in a peripheral conduit vessel, the brachial artery, in 14 young men with CAD and in 11 age-matched, healthy, merle volunteers, Endothelium-dependent vasodilation was determined by measuring the change in brachial artery diameter during increases in flow induced by reactive hyperemia. Endothelium-independent vasodilation was assessed by administration of sublingual nitroglycerin. To ascertain whether flow-mediated vasodilation in humans is mediated by endothelium-derived nitric oxide, brachial artery diameter was measured during reactive hyperemia, before and during administration of the nitric oxide synthase antagonist N-G-monomethyl-L-arginine (L-NMMA). Brachial artery diameter was also measured during intraarterial infusion of acetylcholine and nitroprusside before and after administration of L-NMMA. Flow-induced vasodilation was less in patients with CAD than in healthy volunteers (1.3+/-1.1% vs 6.2+/-0.7%, p